BACKGROUND Secundum atrial septal defect is a common congenital heart disease. Amplatzer septal occluder has become the most commonly used device for its closure. This study was conducted to determine the safety and outcome of atrial septal defect closure with the Amplatzer septal occlude (ASO). METHODS This Case-series was conducted at Armed Forces Institute of Cardiology/National Institute ...

BACKGROUND Congenital heart diseases cause significant childhood morbidity and mortality. Several restricted studies have been conducted on the epidemiology in Nigeria. No truly nationwide data on patterns of congenital heart disease exists. OBJECTIVES To determine the patterns of congenital heart disease in children in Nigeria and examine trends in the occurrence of individual defects across...

Secundum atrial septal defect accounts for 10% of congenital heart disease4 at birth and for 30-40% of cases seen in adults.5 Approximately 300-400 patients undergo surgical closure of atrial septal defect in the United Kingdom each year. Reports of the natural history of atrial septal defect and of the indications for and results of surgery imply that patients become increasingly symptomatic w...

background: despite several reports regarding the use of the occlutech figulla® flex septal occluder (offso) in adults, there are few reports on its use in children. we sought to study the result of the transcatheter closure of atrial septal defect (asd) using the offso in children ≤ 12 years. methods: w e enrolled 45 consecutive patients, ranging from 2.5 to 12 years of age, in two large pedia...

background: the transcatheter closure of the atrial septal defect (asd) has become an alternative technique to surgical procedures . the aim of this study was to assess the immediate, short, and intermediate-term results of the transcatheter closure of the secundum asd with the amplatzer septal occluder (aso) in adult iranian patients. methods: between december 2004 and july 2008, the transcath...

BACKGROUND Most non-chromosomal congenital heart defects are thought to be caused by the interaction of genetic factors involving multiple genes and environmental factors. Families that have several affected members have been reported, however, which suggests that a single autosomal dominant or recessive gene may cause the cardiac defects. A family in which atrioventricular septal defect seemed...

myocardial free wall rupture is a catastrophic complication of acute myocardial infarction, and prognosis will depend on the prompt diagnosis by echocardiography, extension of infarct size, and prompt surgical treatment. free wall rupture concomitant with ventricular septal defect (vsd) may be more complicated for management. a case of a 69-year-old man with myocardial free wall rupture and vsd...

AIMS Pulmonary hypertension (PH) in asymptomatic patients is a rare cause of sudden death. This study aims to determine the incidence of this entity and raise awareness among pathologists. METHODS We retrospectively investigated 44 cases of sudden unexpected death in relation to PH in patients not on antihypertensive therapy. This is the largest pathological study reported. RESULTS We repor...

BACKGROUND/AIM Congenital heart disease (CHD) is a common birth defect. Many studies have reported GATA4 mutations in patients with CHD, mainly septal defects. This study aimed to investigate the GATA4 exon 1 mutation in Egyptian patients with isolated congenital heart defects as a possible causative mutation. MATERIALS AND METHODS Screening for mutations or any sequence variations in exon 1 ...

Four-fifths of the infants with transposition of the great vessels die within the first year of life (Abbott, 1936). Fifty-two per cent. die within the first month and 86% are dead within six months (Keith, Neill, Viad, Rowe, and Chute, 1953). This lesion in some form occurs in 20% of necropsies on patients with congenital heart disease (Keith, Rowe, and Vlad, 1958). In Birmingham, transpositio...