Atrial septal defect (ASD) is the common congenital anomaly which requires surgical interventions. Right atrial thrombus formations after primary suture repairs of the ASD and evidences of thromboembolic complications are extremely rare. Specifically, the cases of thromboembolic complications have high mortality and morbidity risks. Two cases of giant intra-atrial thrombus formation detected in...

Platypnea orthodeoxia is a rare syndrome that describes breathlessness on standing that resolves on lying flat. We present a previously healthy patient who developed platypnea orthodeoxia in her eighth decade of life. Cardiovascular imaging demonstrated an atrial septal defect, extensive Chiari network and atrial septal hypertrophy. We propose the development of lipomatous atrial septal hypertr...

Incidence and Natural History Ventricular septal defect is the commonest congenital heart lesion in childhood and probably accounts for 20% of all heart defects (Keith, Rowe, and Vlad, I958). It has been reported to be the second most common cause of death in children suffering from heart disease (Zacharioudakis, Terplan and Lambert, 1957). An accurate appraisal of the life-span of a child born...

Atrial septal defect (ASD) is a common congenital cardiac anomaly. Even though surgery is the gold standard, percutaneous device closure is gaining popularity because of the short learning curve, cosmetic advantage and relative safety. The long-term implications are open to question. We report here two cases where surgical intervention was required during attempted percutaneous closure and brie...

T HE CLOSE anatomic relationship of the conduction system of the heart to most ventricular septal defects'-5 makes the occurrence of complete heart block a potential risk in the repair of these lesions. In our experience , when complete heart block has developed , it has often proved to be a serious complication. Although reversion to sinus rhythm occurs in the early postoperative period in man...

OBJECTIVE Studies in children with heart disease have been hampered by a lack of easily identifiable patient groups. Currently, there are few prospective population-based registries covering the entire spectrum of heart disease in children. KinCor is a Dutch national registry for children with heart diseases. This paper presents the aims, design and interim results of the KinCor project. METH...

Atrial septal defect (ASD) is a congenital heart defect that is being increasingly treated using percutaneous interventions. However, these techniques are not devoid of complications. One such complication is device embolization. Removal of such closure device poses tremendous risk and consequent complications both by percutaneous retrieval and surgical removal. Herein, we present two cases of ...

BACKGROUND Nitric oxide (NO) produced by endothelial NO synthase (eNOS) plays an important role in the regulation of cell growth, apoptosis, and tissue perfusion. Recent studies showed that mice deficient in eNOS developed abnormal aortic bicuspid valves. The aim of the present study was to additionally investigate the role of eNOS in heart development. METHODS AND RESULTS We examined postnat...

A series of 128 consecutive cases of atrial septal defect in adult patients was analyzed from the standpoint of the course and prognosis. The ages of the patients ranged from 18 to 67 years and the ratio of men to women was 1 to 2. Age distribution when compared with life expectancy tables indicated reduced life expectancy. Clinical analysis revealed that three quarters of the patients were sym...

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