Abstract Background Brucella mellitensis, the most invasive strain of brucella, is the predominant Strain of genus brucella in Iran. It causes variety of hematological abnormalities some of which are frequent and causes difficulties in diagnosis. Objective To find hematological abnormalities of brucellosis in hospitalized patients in an endemic area. Materials and Methods A retrospective ...

Cystic lesions of the pancreas are increasingly recognized. While some lesions show benign behaviour (serous cystic neoplasm), others have an unequivocal malignant potential (mucinous cystic neoplasm, branch- and main duct intraductal papillary mucinous neoplasm and solid pseudo-papillary neoplasm). European expert pancreatologists provide updated recommendations: diagnostic computerized tomogr...

Abstract Background Tyrosine kinase inhibitors (TKIs) revolutionized treatment of chronic myeloid leukemia (CML). However, the first months therapy are crucial, as optimal response is defined achievement molecular milestones at 3, 6 and 12 (mo.) many toxicities, also causing a TKI switch, more frequent in 1st year. Methods To evaluate early (MR) incidence events leading to change during year th...

Of all the gynecologic cancers, ovarian malignancy represents the greatest clinical challenge because it is difficult for early detection, difficult to cure, and it has the highest fatality to case ratio of all the gynecologic malignancies. Many studies have been tried to find a novel strategy on early detection of ovarian cancer. Ultimately, successful screening in asymptomatic women could inc...

In 2002 a study reported that a blood test, based on pattern-recognition proteomics mass spectroscopy analysis of serum, was nearly 100% sensitive and specific to detect ovarian cancer. Plans to introduce a commercial screening test by early 2004 were delayed amid concerns about whether the approach was reproducible and reliable. In this issue of JNCI, two commentaries discuss whether the initi...

The incidence of ovarian cancer is highest in women over 70 years old, and the disease is the leading cause of death from gynecologic malignancies in the United States and Europe. Nevertheless, improving the quality of medical care for elderly women with ovarian cancer continues to be a challenge. This paper presents the major issues related to the surgical management of presumed early-stage ov...