We describe the magnitude and kinetics of plasma viremia and nonstructural protein 1 (sNS1) levels in sequential samples from 167 children with acute dengue, enrolled early in a community study in Vietnam. All children recovered fully, and only 5 required hospitalization. Among those with dengue virus type 1 (DENV-1), plasma viremia was significantly greater in primary (49) than secondary (44) ...

BACKGROUND One of the important causes of death after blast injuries is reduced blood volume, which typically results from hemorrhage but may also result from nonhemorrhagic causes. Hemoconcentration is one such alternate cause of reduced blood volume, but its mechanism is unclear. Because blood is condensed after chest-abdomen blast injuries in rabbits, a series of experiments was conducted to...

The effect of small hematocrit (Hct) increases on cardiac index (cardiac output / body weight) and oxygen release to the microcirculation was investigated in the awake hamster window chamber model, by means of exchange transfusions of homologous packed red blood cells. Increasing Hct between 8-13% from baseline increased cardiac index by 5 31% from baseline (P < 0.05) and significantly lowered ...

The effect of small hematocrit (Hct) increases on cardiac index (cardiac output/body wt) and oxygen release to the microcirculation was investigated in the awake hamster window chamber model by means of exchange transfusions of homologous packed red blood cells. Increasing Hct between 8 and 13% from baseline increased cardiac index by 5-31% from baseline (P < 0.05) and significantly lowered sys...

Acute worsening of renal function is common in hospitalized patients with acute decompensated heart failure and is associated with increased risk of hospital readmission and both in-hospital and postdischarge mortality.1 The pathogenesis of worsening of renal function in hospitalized heart failure patients is thought to be attributable to 2 interdependent multifactorial mechanisms: (1) a short-...

The recent report on “Rapid diagnosis of dengue infection in acute phase” is very interesting. Ahmed and Broor1 noted that “NS1 antigen detection ELISA and realtime RT-PCR were found to be rapid, convenient and efficient tests for diagnosing dengue fever in acute phase”. In fact, there is no doubt that the new tool can help in rapid diagnosis of dengue, however, it is still questionable for its...

In the critical phase of dengue fever, the leakage of intravascular fluid into interstitial space and 3rd space can cause hemoconcentration and severe complications such as dengue shock syndrome (DSS), and it can lead to multiple organ failure, followed by death. Close monitoring, early detection and prompt management are the keys in successful treatment. In a hemodynamically unstable patient, ...