Hemoglobin A1c (Hb A1c) 1 is a mainstay of diabetes diagnosis and management that allows clinicians to estimate the recent mean blood glucose concentration of a patient. Glycation of hemoglobin is an irreversible, nonenzymatic process that depends on the glucose concentration in red blood cells (RBCs), and Hb A1c represents the integrated glucose concentration in RBCs over their life span. RBC ...

HIGHLIGHTS The combined use of fasting plasma glucose and hemoglobin A1c test is associated with significantly higher diagnostic rates of prediabetes across age, race/ethnicity, and BMI than using only one test.Combined use of fasting plasma glucose, hemoglobin A1c, and oral glucose tolerance test do not improve the overall and gender-specific prediabetes prevalence beyond what is observed usin...

Hemoglobin A1c (Hb A1c) 2 is the analyte most commonly measured in clinical laboratories for patients with diabetes mellitus. Physicians use Hb A1c to monitor long-term glycemic control, adjust therapy, and predict complications of diabetes. Recently, Hb A1c was added as a criterion for the diagnosis of diabetes. Unlike most analytes, many patients with diabetes know their Hb A1c value and are ...