نتایج جستجو برای: hemophilic arthropathy

تعداد نتایج: 7023  

2015
Paul E. Monahan Junjiang Sun Tong Gui Genlin Hu William B. Hannah David G. Wichlan Zhijian Wu Joshua C. Grieger Chengwen Li Thipparat Suwanmanee Darrel W. Stafford Carmen J. Booth Jade J. Samulski Tal Kafri Scott W.J. McPhee R. Jude Samulski

Vector capsid dose-dependent inflammation of transduced liver has limited the ability of adeno-associated virus (AAV) factor IX (FIX) gene therapy vectors to reliably convert severe to mild hemophilia B in human clinical trials. These trials also identified the need to understand AAV neutralizing antibodies and empty AAV capsids regarding their impact on clinical success. To address these safet...

Journal: : 2023

Aim: The aim of the study was to investigate whether multimorbidities, comorbidities, and therefore polypharmacy increase with age in hemophilia A B patients followed Ege University Adult Hemophilia Thrombosis Center. Materials Methods: were retrospectively evaluated. Patients'demographic data, medical information about hemophilic arthropathy, viral infections hepatitis C virus (HCV), body mass...

Journal: :Gematologiia i transfuziologiia 2023

Introduction. Hemophilia is an X-linked hereditary blood clotting disorder caused by insufficiency of factor VIII or IX that affects mainly men. In extremely rare cases, the disease can be observed in women, which most often associated with asymmetric inactivation X chromosome. The severity hemophilia women does not differ from Aim – to present a clinical observation surgical treatment stage 4 ...

2015
Toshiyuki Tateiwa Yasuhito Takahashi Tsunehito Ishida Kosuke Kubo Toshinori Masaoka Takaaki Shishido Keiji Sano Kengo Yamamoto

It has been recognized that perioperative hemostasis management after joint-replacement surgery for hemophilia patients is complicated and cumbersome, due to the necessity of rigorous monitoring for clotting-factor levels throughout the infusion. Between 2005 and 2014, we examined seven patients with hemophilia A (ten joints: six hips and four knees) receiving total hip or knee arthroplasty (TH...

2017
Young Shil Park Won-Ju Shin Kang-Il Kim

BACKGROUND Total knee arthroplasty (TKA) has become the treatment of choice for end-stage hemophilic arthropathy of the knee. Theoretically in hemophilia A, perioperative continuous infusion (CI) of factor VIII (FVIII) would provide a more consistent FVIII level than general bolus injections (BI) in TKA. Current study was designed to evaluate the effectiveness of CI of coagulation factor concen...

2016
Cheng Liu Jun Guo Qiu Cui Dingfeng Li Yanjun Zeng

INTRODUCTION The incidence of subclinical hemophilic arthritis is low, with this case reports and literature review, we hope clinicians could pay more attention to the diagnosis of subclinical hemophilic arthritis and prevent the misdiagnosis and mistreatment. CASE PRESENTATION We analyzed the imaging feature, and therapy of a subclinical hemophilia case with hip lesion by reporting its clini...

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