increase haemoglobin synthesis and erythro-poiesis. Further clinical and fundamental research is warranted to establish the possible beneficial effects of (oral) iron chelation treatment on RA activity and the anaemia of chronic disease. of hydroxyl radicals in the presence of ferritin and hemosiderin. Is hemosiderin formation a biological protective mechanism? Biochem J 1986; 234: 727-31. Iron...

LTHOUGH FERRITIN has been shown to be present in many tissues of the body, the bulk of it is found in the cells of the liver, the spleen, and the bone marrow.”2 Ferritin aggregates with other cellular constituents, it is believed, to form insoluble complexes called hemosiderin.3 Ferritin and hemosiderin constitute the body’s storage depot of iron. Most of this iron supply, derived chiefly from ...

Iron-deposition is a metabolic biomarker of macrophages in both normal and pathological situations, but the presence of iron in tumor and metastasis-associated macrophages is not known. Here we mapped and quantified hemosiderin-laden macrophage (HLM) deposits in murine models of metastatic breast cancer using iron and macrophage histology, and in vivo MRI. Iron MRI detected high-iron pixel clus...

BACKGROUND Superficial siderosis (SS) is the occult deposition of hemosiderin within the cerebral cortex due to repeat microhemorrhages within the central nervous system. The collection of hemosiderin within the pia and superficial cortical surface can lead to injury to the nervous tissue. The most common presentation is occult sensorineural hearing loss although many patients have been misdiag...

Intranodal palisaded myofibroblastoma (IPM) is a benign mesenchymal neoplasm originating from smooth muscle cells and myofibroblasts. It is characterized by spindle cells, amianthoid fibers, and by the proliferation of hemosiderin-containing histiocytes in the lymph node. A nodular lesion was excised from the inguinal region of an 80-year-old male patient. Macroscopic examination of a section o...

An outbreak of bacterial septicemia in female silver carp Hypophthalmichthys molitrix , which caused significant death the fish Yantian Reservoir, was investigated. The pathogen isolated from diseased and identified as Aeromonas veronii utilizing biochemical characteristics molecular methods analyses. artificial infection experiment indicated that strain 100% mortality juvenile mature with eggs...

Abstract Brain metastases (BrM) commonly occur in renal cell carcinoma (RCC) and often present with hemorrhagic features. The distribution patterns of BrM RCC their associations clinical outcomes remain unclear. We conducted a retrospective neuroanatomical analysis combined review our surgical cohort. Sixty-seven BrMs from 46patients (age 63±10years, 25males) were included. majority (55%) found...

Sclerotherapy is one of the most popular and common techniques for removal delated reticular veins telangiectasias on lower limbs. Despite vast pooled experience, this procedure can be accompanied by a number undesirable side effects, which post-injection hyperpigmentation, frequency reaches 80%, unpleasant one. The development postsclerotherapy hyperpigmentation (PSHP) associated with extravas...

The incidence and severity of chronic intravascular hemolysis was evaluated in a total of 41 patients following mitral valve replacement. Valve replacement was with a gamma-radiated frame-mounted aortic homograft in 21 patients and with a composite seat Starr-Edwards prosthesis, model 6310 or 6320, in 20 patients. The parameters used to assess hemolysis were hemoglobin, hematocrit, reticulocyte...

The thrombospondins are a family of extracellular calcium-binding proteins that modulate cellular phenotype. Thrombospondin-1 (TSP-1) reportedly regulates cellular attachment, proliferation, migration, and differentiation in vitro. To explore its function in vivo, we have disrupted the TSP-1 gene by homologous recombination in the mouse genome. Platelets from these mice are completely deficient...