background: the association between hepatitis b virus (hbv) mutations and hepatocarcinogenesis were reported in the literature. preference for g over c in the leading dna strand has been reported to account for the asymmetry in nucleotide (nt) composition. the aim of this study was to analyze the complete genome sequence and compositional asymmetry of hbv in different stages of hepatitis b. met...

objectives thus, the present study aimed to determine if fas and fasl promoter polymorphisms are associated with the clinical outcome of hbv infection. patients and methods dna samples were obtained from the infected individuals including chronic carrier (n = 50), chronic hepatitis (n = 50), cirrhosis (n = 25), naturally recovered (n = 26) and compared with those of their matched healthy contro...

conclusions the occurrence of he is associated with hyponatremia and ppi use in patients with aclf. results in univariate analysis, patients with he in aclf had a significantly higher rate of ppi use (89.1%) compared with non-he (63.6%, p = 0.001). in addition, clinical and standard laboratory variables were significantly different between the two groups regarding the infection rate, hyponatrem...

context hepatocellular carcinoma (hcc) is one of the most common cancers in the world but with a striking geographical variation in incidence; most of the burden is in developing countries. this geographic variation in hcc incidence might be due to geographic differences in the prevalence of various etiological factors. evidence acquisition here, we review the epidemiological evidence linking d...

conclusions fluctuations in serum alt levels may change the prognosis of a hbv inactive carrier state. objectives this study aimed to determine the incidence rate and patterns of alt fluctuations and prognostic values for the development of chronic hbv e antigen (hbeag)-negative hepatitis b (chb), hbv surface antigen (hbsag) seroclearance, and liver-related complications. patients and methods t...

Case Report: Some viruses have been reported to cause respiratory and gastroenteric infections simultaneously. In this case we present isolation of human respiratory virus (RSV) type B from diarrheal sample of a 12 months' child with acute gastroenteritis. Results: The results indicated the presence of RSV subtype B genome in all three stool samples. Moreover, no sign of co-infections with oth...

Manufacturing new Hepatitis B virus vaccines, specifically by the use of nanoparticles, is of high global interest. In this paper, a new biocompatible and biodegradable structure of nano-sized hepatitis B virus’ surface antigen (HBsAg) was generated by conjugation with dendrimers, a low cost biodegradable and biocompatible polymer. The physicochemical properties of the conjugate were characteri...

dna coding for the core antigen from hepatitis b virus (hbcag) was amplified, cloned and propagated in e. coli. the core protein was expressed in e. coli and the product was readily detected by western blot. this protein can be used as a diagnostic material in serum screening tests. to increase the level of expression of this antigen in bacteria, two plasmids were constructed in which the gene ...

hepatitis b infection is the main cause of liver related mortality in many countries including iran. liver transplantation in cirrhosis due to hbv infection before 1990 was an absolute contraindication. recurrent infection was a significant event in post liver transplant setting and resulted in increased risk of graft failure and death except successful transplanted individuals. advances in ant...