Amyloidosis is induced by deposition of amyloid proteins in various organs. Both systemic and localized type amyloidosis present with a variety of skin manifestations. Based on biochemical and immunological aspects, amyloid proteins are subdivided into several subtypes from different origins. Amyloid fibrils in primary and multiple myelomaassociated systemic amyloidosis are composed of immunogl...

Amyloidosis refers to a group of protein misfolding diseases characterized by deposition of a particular amyloid protein in various organs and tissues of animals and humans. Although there are other components present in the deposit, the amyloid protein fibril is the main component of the amyloid substance. The amyloid substance differs in protein composition depending upon the types of amyloid...

Familial amyloidotic polyneuropathy (FAP) has a high prevalence in Portugal, and the most common form of hereditary amyloidosis is caused by an amyloidogenic variant of transthyretin (TTR) with a substitution of methionine for valine at position 30 (V30M). Until now, the available efficient therapy is liver transplantation, when performed in an early phase of the onset of the disease symptoms. ...

AIM The aim of this study was to evaluate the diagnostic utility of high-sensitivity cardiac troponin T (hs-cTnT) levels in discriminating cardiac amyloidosis from patients with cardiac hypertrophy caused by aetiologies other than cardiac amyloidosis. METHODS AND RESULTS Serum hs-cTnT levels were measured in 96 patients with cardiac amyloidosis (light chain: 23, wild-type transthyretin amyloi...

Hereditary fibrinogen Aα-chain amyloidosis (Aα-chain amyloidosis) is a type of autosomal dominant systemic amyloidosis caused by mutations in fibrinogen Aα-chain gene (FGA). Patients with Aα-chain amyloidosis have been mainly reported in Western countries but have been rarely reported in Asia, with only five patients with Aα-chain amyloidosis being reported in Korea, China, and Japan. Clinicall...

A conception of amyloidosis as merely a complication of chronic syphilitic, tuberculous or septic disease of bones and joints or of chronic intrathoracic sepsis is no longer adequate. This older view has had to be modified as the association of amyloidosis with other diseases came to be recognized: the predisposing diseases are now known to include rheumatic and rheumatoid affections, myelomato...

It takes at least several months from the suspicion of amyloidosis to diagnosis. This delays start specific therapy. Diagnosis should consist not only in differential diagnosis and confirmation diagnosis, but also determining type amyloidosis. The case report is interesting that paraclinical diagnostics determined picture characteristic ATTR-amyloidosis with involvement peripheral nervous syste...