The effects of oestrogenic exposure upon exposure indicators and reproductive success in a marine fish were investigated using a series of short and long-term exposures of the sand goby (Pomatoschistus minutus) to oestrogenic materials. A 140 bp cDNA probe for sand goby vitellogenin (VTG) was used to measure hepatic VTG mRNA expression. Effects on other novel and “classical” biomarkers of oestr...

Hepatic ischemia-reperfusion (IR) injury is a clinical problem that leads to cellular damage and organ dysfunction mediated mainly via production of reactive oxygen species and inflammatory cytokines. Vinpocetine has long been used in cerebrovascular disorders. This study aimed to explore the protective effect of vinpocetine in IR injury to the liver. Ischemia was induced in rats by clamping th...

Tolvaptan is a selective vasopressin V2 receptor antagonist, approved in several countries for the treatment of hyponatremia and autosomal dominant polycystic kidney disease (ADPKD). No liver injury has been observed with tolvaptan treatment in healthy subjects and in non-ADPKD indications, but ADPKD clinical trials showed evidence of drug-induced liver injury (DILI). Although all DILI events r...

Folate is generally considered as a safe water-soluble vitamin for supplementation. However, we do not have enough information to confirm the potential effects and safety of folate supplementation and the interaction with vitamin B(12) deficiency. It has been hypothesized that a greater methyl group supply could lead to compensation for vitamin B(12) deficiency. On this basis, the present study...

The current study addresses the influence of Moringa oleifera leaves nanoparticles (MO-NPs) on growth, biochemical, immunological, and hepatic antioxidant alterations induced by zinc oxide toxicity in Nile tilapia (O. niloticus). Fish (N = 180) were divided into four groups with replicates. first one was set as a control group second fed an MO-NPs-enriched diet (2.5 g/kg diet). third exposed to...

Azoxystrobin (AZX) is a broad-spectrum systemic fungicide massively used worldwide. Its mode of action consists in the inhibition mitochondrial respiration decreasing synthesis ATP and leading to oxidative stress target fungus. However, whether this effect occurs non organisms has been scarcely studied. The objectives work were (1) evaluate biomarkers stress, hematological, physiological genoto...

Activation of hepatic stellate cells (HSCs) and subsequent uncontrolled accumulation of altered extracellular matrix (ECM) underpin liver fibrosis, a wound healing response to chronic injury, which can lead to organ failure and death. We sought to catalogue the components of fibrotic liver ECM to obtain insights into disease etiology and aid identification of new biomarkers. Cell-derived ECM wa...

Obesity and type 2 diabetes mellitus (T2DM) are characterized by underlying low-grade chronic inflammation. Metformin has been used as the first line of therapy in T2DM it decreases hepatic glucose production intestinal absorption, enhances insulin sensitivity weight loss, is known to ameliorate The mechanisms through which metformin exerts its effect remain unclear. Proteomics emerged a unique...