objective(s): our present study sought to evaluate hepatoprotective and antioxidant effects of methanol extract of azolla microphylla phytochemically synthesized gold nanoparticles (gnap) in acetaminophen (apap) - induced hepatotoxicity of fresh water common carp fish.materials and methods: gnap were prepared by green synthesis method using methanol extract of azolla microphylla.  twenty four f...

hepatic ischemia-reperfusion (i/r) is a common phenomenon during liver surgery, transplantation, infection and trauma which results in damage and necrosis of the hepatic tissue through different pathways. mechanisms involved in i/r damage are very intricate and cover several aspects. several factors are involved in i/r-induced damages; briefly, decrease in sinusoidal perfusion and atp generatio...

Biliary excretion is the major elimination route of copper, therefore increased hepatic copper concentrations could be caused by cholestasis. Hepatic copper accumulation is cytotoxic and results in fibrosis in hepatic tissues. Aim: The aim of this work is to determine the concentration of copper in serum and hepatic tissue in infants with cholestasis and its impact on liver function tests. Subj...

Many hepatoprotective herbal preparations have been recommended in alternative systems of medicine for the treatment of hepatic disorders. No systematic study has been done on protective efficacy of Capparis spinosa (Capparidaceae) to treat hepatic diseases. Protective action of C. spinosa ethanolic root bark extract was evaluated in this study in an animal model of hepatotoxicity, which was in...

In India, a number of medicinal plants and their formulations are used to cure hepatic disorders in traditional systems of medicine. No systemic study has been done on protective effect of Cucumis trigonus Roxb. (Cucurbitaceae) to treat hepatic diseases. Protective action of C. trigonus fruit extracts was evaluated in this study in animal model of hepatotoxicity, which was induced by carbon tet...

Many hepatoprotective herbal preparations have been recommended in alternative systems of medicine for the treatment of hepatic disorders. No systematic study has been done on protective efficacy of Capparis spinosa (Capparidaceae) to treat hepatic diseases. Protective action of C. spinosa ethanolic root bark extract was evaluated in this study in an animal model of hepatotoxicity, which was in...

PURPOSE Warm hepatic ischemia-reperfusion (I/R) injury can lead to multiorgan dysfunction. The aim of the present study was to investigate whether acute liver I/R does affect the function and/or structure of remote organs such as lung, kidney, and heart via modulation of extracellular matrix remodelling. METHODS Male Sprague-Dawley rats were subjected to 30 min partial hepatic ischemia by cla...