We report a case of methimazole-induced acute hepatic failure, which occurred 17 weeks after initiation of the drug in a 43-year-old man with hyperthyroidism and hepatitis B surface antigenemia. Postmortem needle autopsy of the liver revealed an established micronodular cirrhosis secondary to hepatitis B with moderate septal/portal inflammation, marked cholestasis and scattered acidophilic bodi...

Background: Hepatitis is among the major health problems, especially in developing countries. During past decades, the association between type of blood group (ABO) and hepatitis B and C virus has always been discussed. This study was designed to investigate the possible association between type of ABO blood group and chronic hepatitis B and C infection. Methods: In the present analytical stud...

The correlation and kinetics of hepatitis C virus (HCV) RNA and HCV core antigen levels in chronic hepatitis C patients treated with pegylated interferon + ribavirin were evaluated in order to envision a combined use of the two assays in therapy monitoring. HCV core antigen levels by a chemiluminescent immunoassay (Abbott ARCHITECT) and HCV-RNA levels by branched DNA (bDNA) or real-time PCR hav...

background the transmission of hepatitis b virus (hbv) is parenteral, sexual and prenatal. prevention of vertical transmission of hbv is extremely important, because hbv infection in early life usually results in a chronic carrier state. there has been so much debate about hepatitis b surface antigen (hbsag) screening in pregnant women. objectives the aim of this study was to determine the prev...

conclusions the significant number of coinfected hiv-hcv patients only had hbcab positive test without detectable hbv-dna. further studies for detection of hbv-dna in both serum and liver biopsy specimens may help clarify the impact of hbv infection in coinfected hiv/hcv patients. results of 103 hiv-hcv coinfected patients, both hbsag and hbcab were positive in 7 patients (6.8%), negative in 44...

There are two hypotheses explaining a fulminant outcome after hepatitis B virus (HBV) infection, both of which may be applicable at the same time: (i) basal core promoter (BCP) mutations increase viral replication, allowing rapid spread of the virus through the liver, and (ii) pre-core (pre-C) mutations abrogating hepatitis B e antigen (HBeAg) synthesis remove its tolerogenic effect, leading to...

OBJECTIVE The risk of transmitting hepatitis B virus from donors who are positive for hepatitis B core antibody but negative for hepatitis B surface antigen has been a major concern in liver transplantation. In the Kingdom of Saudi Arabia the overall prevalence of hepatitis B core antibody among the general population was reported to be very high indeed. The purpose of this study is to establis...

OBJECTIVES This study measured age-specific seroprevalence of HIV, hepatitis B virus, and hepatitis C virus (HCV) infection among injection drug users (IDUs) admitted to drug treatment programs in 6 US cities. METHODS Remnant sera collected from persons entering treatment with a history of illicit drug injection were tested for antibodies to HIV, hepatitis C (anti-HCV), and hepatitis B core a...

Hepatitis B is a liver inflammation caused by hepatitis B virus (HBV) and can be diagnosed in clinical stage by hepatitis B core antibody from IgM class (anti-HBcIgM). Hepatitis B core antibody from IgG class (Anti-HBcIgG) appears quickly after IgM, reaching high titers in chronic hepatitis, and remains even after cure. Since hepatitis B core antibody (anti-HBc) is the first antibody identified...

conclusions there is an as yet unexplained association between hcv and host parameters with unknown mechanisms in patients with chronic hcv infection. the assessments of core aa 70 substitution and polymorphisms near the ifnl3 gene could offer promising steps to improve the management of patients with hcv. background molecular studies have demonstrated that the hepatitis c virus (hcv) genotype ...