Hepatocellular carcinoma (HCC) is lethal malignancy showing high relapse rates after curative resection in early-stage. Genomic features of stem cell-like cancer cells contributing aggressive tumor biology HCC remains unclear. The aim this study to understand underlying associated with stemness apply precise therapeutic strategies for resectable early-stage hepatocellular carcinoma. Using human...

Abstract Background Hepatocellular carcinoma (HCC) is an increasingly common disease and classified as one of the most cancers leading to mortality worldwide. Only a small percentage patients with this are eligible curative treatment. Quite often main reason late diagnosis disease. In last decade, Nobel prize awarded discovery volatile organic compounds in breath opened frontiers for new diagno...

In recent years, the incidence of hepatocellular carcinoma (HCC) has been increasing worldwide, and its high mortality seriously threatens public health. Early detection and treatment are crucial to improving the survival rate. Imaging examination widely used for the diagnosis of HCC and provides a non-invasive means of tumor visualization. The rapid development of medical imaging technology is...

Hepatocellular carcinoma (HCC) occurs in patients with chronic liver damage, inflammation and cirrhosis. The facilitators involved increasing the HCC risk damaged are yet to be discovered. Diet lifestyle have a profound effect on HCC. term “gut axis” describes bidirectional relationship between gut, which both anatomically functionally related. Chronic damage is characterised by increased intes...

Abstract Some studies have reported that activated ribosomes are positively associated with malignant tumors, especially in hepatocellular carcinoma (HCC). The RNA-binding protein PNO1 is a critical ribosome rarely human tumors. This study aimed to explore the molecular mechanisms of HCC. Using 150 formalin-fixed and paraffin-embedded samples 8 fresh samples, we found high expression HCC tumor ...

Distal-less 4 (DLX4) is a member of the DLX family of homeobox genes. Recent reports have suggested that abnormal expression of DLX4 is present in several types of human tumors, including breast cancer, leukemia and colon cancer. However, the function and the mechanistic regulation of DLX4 in hepatocellular carcinoma (HCC) are elusive. In the present study, a proportion of hepatocellular carcin...

Background Hepatocellular carcinoma (HCC) is a high-incidence and significant cause of cancer globally. HCC the world's third most common death-related sixth tumor. In HCC, various cellular signaling activated to ensure malignancy transformation, angiogenesis, metastasis. The efficient pathway in mitogen-activated protein kinase (MAPK), which controls regulates apoptosis. mutant k-ras gene led ...

Hepatocellular carcinoma (HCC) is the most often primary cancer of the liver and is one if the leading cause of cancer-related death worldwide. The incidence of HCC has geographic distribution with the highest levels in countries with developing economies. Patients with hepatocellular carcinoma have poor prognosis despite the achievements in surgery techniques and other therapeutic procedures a...

Hepatocellular carcinoma (HCC) is one of the most frequent malignancies, so early diagnosis is crucial to HCC. In recent years, with the rapid development of proteomics and glycomics, new various serum markers related hepatocellular carcinoma were found in succession. Although it is reported that golgi protein 73 (GP73) and its corpora heterogenium (Fucosylated gp73, Fuc-gp73) can be the serum ...

conclusions hbv and hcv are important culprits of hcc in emro countries and the middle east and different nations need different strategies to tackle them accordingly. countries with high rates of hbv such as turkey should continue their hbv vaccination and also increase sanitation. nations with high hcv rates such as egypt should maintain their blood product monitoring in addition to increased...