L-Cysteine-glutathione disulfide, a ubiquitous substance present in mammalian cells, was shown to be highly effective in protecting mice against acetaminophen-induced hepatotoxicity. Since the corresponding D-cysteine-glutathione disulfide was totally ineffective in this regard, an enzymatic mechanism that provides glutathione directly to cells is postulated.

Several studies have been shown that accelerated apoptosis is involved in post-exercise lymphocytopenia and tissue damage after high-intensity exercise. Ganoderma tsugae (GT) is one of the well-known medicinal mushrooms that possess various pharmacological functions. This mushroom has traditionally been used for health promotion purposes. This study investigates the hepatoprotective effects of...

Endophytes have continued to gain fame due their ability produce an array of secondary metabolites within the host system with huge untapped pharmacological potentials. This study was carried out further identify and isolate novel therapeutic compounds from Fusarium equiseti, Endophytic fungus isolated leaves Ocimum gratissimum. fungal isolation, fermentation, extraction were using standard lab...

Purpose: To determine the in vivo and vitro hepatoprotective effects of Ficus carica.Methods: The methanol leaf extract carica L was further fractionated into n-hexane, ethyl acetate aqueous fractions. For study, male albino mice were divided twelve groups. Hepatotoxicity induced using carbon tetrachloride (CCl4). F. its fractions administered at doses 200 400 mg/kg. Silymarin used as standardh...

Farnesoid X receptor (FXR) is a bile acid-activated transcription factor that is a member of the nuclear hormone receptor superfamily. Fxr-null mice exhibit a phenotype similar to Byler disease, an inherited cholestatic liver disorder. In the liver, activation of FXR induces transcription of transporter genes involved in promoting bile acid clearance and represses genes involved in bile acid bi...