Anxiolytic kava products have been associated with rare but severe hepatotoxicity in humans. This adverse potential has never been captured in animal models, and the responsible compound(s) remains to be determined. The lack of such knowledge greatly hinders the preparation of a safer kava product and limits its beneficial applications. In this study we evaluated the toxicity of kava as a singl...

Recently Bartoli et all described a patient with acute hepatic necrosis that occurred two days after treatment with hydrallazine 50 mg daily. The diagnosis was supported by biopsy and rechallenge with the drug. The patient was definitely jaundiced and complained of right upperquadrant pain with nausea and vomiting. We think that our case is important because it provides corroborative evidence o...

Andrographis paniculata (Burm.f.) Nees (Acanthaceae), a plant widely used as traditional herbal medicine in many countries, has drawn attention of the researchers in recent years. Its major constituents are diterpenoids and flavonoids. This article reviews the anti-hepatotoxic effects of A. paniculata extract and derivative compounds, such as andrographolide, the major active compound, most stu...

Dear Editor: Recently, in this journal Denham et al. (2002) and (within the same paper) Whitton et al. published their ideas about the influence of glutathione in aqueous preparations respectively low alcoholic tinctures of kava (Piper methysticum roots.html) on the safety of intake regarding adverse liver reactions. Even though the theory presented is highly interesting, and deserves a closer ...

The effect of administration of graduated dose of aqueous leaf extract of Euphobia lateriflora on ALT, AST, ALP, bilirubin, total protein, creatinine and urea was determined to acertain the toxic effect of the extract on the liver and kidney. Significantly lower levels of AST and urea (p < 0.05) were observed in group administered with 100mg/kg leaf extract. There was no significant difference ...

Eight pregnant Sprague-Dawley rates were exposed to 10 ppm halothane 8 hours/day and 5 days/week throughout pregnancy. Liver samples were obtained from the pups for electron microscopy. Degenerative changes such as myelin-figure formation, focal-cytoplasmic degradation; fatty changes and cellular necrosis were observed. Leukocytic infiltration and phagocytosis of the cellular debris by Kupffer ...

Background and objectives: A key aspect of cisplatin-induced hepatotoxicity is oxidative stress. The current study was conducted to show, for the first time, the restoring and synergistic effects of morin and hesperidin against oxidative stress in hepatotoxicity. Methods: Fourty-two Wistar albino rats were randomly divided into seven groups: group A (control), ...