BACKGROUND Studies suggest an important role of autophagy as a target for cancer therapy. We constructed a "disease-gene-drug" network using the modular approach of bioinformatics and screened herbal monomers demonstrating functions related to autophagy regulation. METHODS Based on the microarray results of the gene expression omnibus (GEO) database (GSE2435 and GSE31040, starvation-induced a...

CONTEXT Herbal remedies are used to treat a large variety of diseases, including blood-related disorders. However, a number of herbal preparations have been reported to cause variations in clotting time, this is mainly by disruption of the coagulation cascade. OBJECTIVE The compiling of plants investigated for effects on the coagulation cascade. METHODS Information was withdrawn from Google...

OBJECTIVES This study was conducted to clarify the analgesic effect of toad cake and toad-cake-containing herbal drugs. METHODS We counted the writhing response of mice after the intraperitoneal administration of acetic acid as a nociceptive pain model and the withdrawal response after the plantar surface stimulation of the hind paw induced by partial sciatic nerve ligation of the mice as a n...

livestock are an integral part of the agriculture sector and encompass a great impact on the national economy. an eco-friendly alternative to enhance production, prevent and treat disease conditions of animal is a great challenge for animal nutritionists. keeping farm animals healthy is necessary to obtain healthy animal products. the use of naturally occurring compounds like herbs, herbal prep...

OBJECTIVE With the growing interest in herbal therapies among persons with rheumatoid arthritis, there exists a need for investigation into their safety and efficacy. The purpose of this study was to conduct a systematic review to examine the evidence for the use of herbal medicines for RA based on randomized clinical trials (RCTs). METHODS A computerized search of eight electronic databases ...

Patients receiving anti-retroviral drug treatment are sometimes simultaneously taking herbal remedies, which may result in pharmacokinetic herb-drug interactions. This study aimed to determine if pharmacokinetic interactions exist between selected commercially available herbal products (i.e., Linctagon Forte(®), Viral Choice(®) and Canova(®)) and indinavir in terms of in vitro transport and met...

BACKGROUND Lack of regulatory capacity limits the conduct of ethical and rigorous trials of herbal medicines in developing countries. Sharing ethical and regulatory experiences of successful herbal trials may accelerate the field while assuring human subjects protection. The methods and timelines for the ethical and regulatory review processes for the first drug regulatory authority approved he...