Encephalitides, an acute infection of the brain parenchyma, are characterized by fever, headache and altered consciousness. Neurological deficits and focal or generalized epileptic seizures may also be seen. There are important differences in clinical presentations between encephalitides caused by viruses. While some viral encephalitides, such as Herpes simplex virus type-1 (HSV type-1) encepha...

A patient with AIDS developed chronic, progressive encephalitis. Pathologic changes indicated that the encephalitis was produced primarily by a human herpesvirus. Hybridization of radiolabeled RNA probes transcribed from cloned DNA fragments of varicella-zoster virus (VZV), herpes simplex virus, cytomegalovirus, and the human immunodeficiency virus to DNA extracted from the patient's brain iden...

Herpes simplex virus type 1 (HSV-1) is the leading cause of virus-induced encephalitis; however, the viral genes that regulate encephalitis have not been well characterized. In this study, we tested whether the LAT (latency-associated transcript) locus regulates the frequency of encephalitis in male or female mice. Male BALB/c mice are more susceptible to HSV-1-induced encephalitis than age-mat...

Three children are described in whom herpes simplex encephalitis (HSE) followed a clearly biphasic course. The secondary deterioration may be due to a resurgence of the viral infection and calls into question the adequacy of current treatment regimens for HSE. Alternatively, a postinfectious neuroallergic process may be active in which case immunomodulatory treatment might be more appropriate t...

Acute Encephalitis Syndrome (AES) is one of the important health problems in childhood that leads to severe morbidity, mortality and sequelae. Herpes Simplex Virus (HSV) attributing towards such viral encephalitis carries importance with respect to its global prevalence challenging pathogenesis and morbidity outcomes. This report provides a review on several studies on epidemiology, pathogenesi...

Recent work has shown that the new antiviral acyclovir (acycloguanasine) is a highly effective antiviral drug against the herpes simplex virus."2 It acts mainly on virally infected cells by blocking viral particle formation before the particles pass through the nuclear membrane3 by means of inhibiting viral DNA polymerase after being converted by virally specific thymidine kinase.4 In tissue cu...

BACKGROUND AND OBJECTIVES Encephalitis can cause a severe public health problem. The main aim of this research was to evaluate the medical laboratory results of patients with Herpes Simplex Virus (HSV) encephalitis. MATERIALS AND METHODS Diagnosis of encephalitis for these patients was firstly based on a clinical profile for Herpes Simplex Encephalitis (HSE), plus either a detected HSV1&2-DNA...

OBJECTIVE To report the frequency of coexisting herpes viruses (herpes simplex virus 1 [HSV-1] or HSV-2, varicella zoster virus, Epstein-Barr virus [EBV], cytomegalovirus, or human herpes virus 6 [HHV-6]) and autoantibodies in patients with encephalitis (herpes or autoimmune) in clinical laboratory service. METHODS Three groups were evaluated for herpes viruses and antibodies: group 1-patient...