Detection of novel DNA sequences in Kaposi's sarcoma (KS) and AIDS-related body cavity-based, non-Hodgkin's lymphomas suggests that these neoplasms are caused by a previously unidentified human herpesvirus. We have characterized this agent using a continuously infected B-lymphocyte cell line derived from an AIDS-related lymphoma and a genomic library made from a KS lesion. In this cell line, th...

To study the relationships between herpesvirus recently isolated from different pinniped species, antigenic and genetic analyses were performed. First, herpesviruses isolated from North American harbour seals (Phoca vitulina), a Californian sea lion (Zalophus californianus) and a European grey seal (Halichoerus grypus) were examined in an enzyme immunoassay (EIA) with a panel of monoclonal anti...

Herpesvirus genomes exist and replicate as episomes inside the host cell nucleus during latent infection. Chiu et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201702013) find that unlike Epstein-Barr virus, which partitions viral genomes faithfully during cell division, Kaposi's Sarcoma-associated herpesvirus clusters viral genomes into loci that are distributed unequally to daughter ce...

The huge amount of experimental and clinical observations supporting the possible involvement of human herpesvirus 8 (HHV-8) or Kaposi sarcoma herpesvirus (KSHV) in human lymphoproliferative diseases was critically reviewed during a workshop organized by the Italian Society for Experimental Hematology in Florence, Italy, on July 3rd, 1997. The organizers have prepared this report for the reader...

Alcelaphine herpesvirus type 1, a rhadinovirus causing malignant catarrhal fever of ruminants, has an 1959 nucleotide open reading frame with significant homologies to semaphorin genes. While truncated genes of similar structure have been found in poxviruses, this is the first known example of a semaphorin-like gene in a herpesvirus.

Elephant endotheliotropic herpesvirus 1A is a member of the Proboscivirus genus and is a major cause of fatal hemorrhagic disease in endangered juvenile Asian elephants worldwide. Here, we report the first complete genome sequence from this genus, obtained directly from necropsy DNA, in which 60 of the 115 predicted genes are not found in any known herpesvirus.

By use of monoclonal antibodies cross-reactive with Marek's disease virus and herpesvirus of turkeys, three glycoproteins (for Marek's disease virus, gp115/110, gp63, and gp50; for herpesvirus of turkeys, gp115, gp62 and gp52) related to virus neutralization were identified. Immunization of chickens or rabbits with these glycoproteins purified by affinity chromatography resulted in production o...

Kaposi's Sarcoma (KS) signified the AIDS epidemic in the 1980's and led to the discovery of the eighth human herpesvirus, KS-associated herpesvirus (KSHV), as the causative agent for this disease. Today we know a lot about KSHV and can begin to understand, diagnose and treat KS as a viral disease rather than another sarcoma.

A central feature of herpesvirus biology is the ability of herpesviruses to remain latent within host cells. Classically, exposure to inducing agents, like activating cytokines or phorbol esters that stimulate host cell signal transduction events, and epigenetic agents (e.g., butyrate) was thought to end latency. We recently showed that Kaposi's sarcoma-associated herpesvirus (KSHV, or human he...

primary kaposi sarcoma of penis is very rare. we will introduce a 47 years old male patient referred to our clinic from dermatology service, in this report. the patient suffered from itchy penile papules around coronal region. the lab tests had revealed a negative serology of hiv but tissue pcr was positive for human herpesvirus-8 (hhv8).  histological findings were compatible with kaposi sarco...