OBJECTIVE Ischemia-modified albumin (IMA) is a sensitive biomarker of myocardial ischemia. However, data on IMA levels in acute heart failure (HF) are still lacking. In this study, we aimed to evaluate serum IMA levels in acute decompensated HF and the effects of dobutamine and levosimendan treatments on IMA levels. METHODS This was a prospective, multicenter study that included 70 patients h...

The purpose of the present study was to assess the effect of an exercise training program conducted concurrently with a high-fat (HF)-diet regimen on the induction of hepatic steatosis. Two groups of rats were fed either a standard (SD) or a HF (40% kcal) diet for 8 wk and were additionally assigned either to a sedentary (Sed) or a treadmill-trained (TR) group. Training (5 days/wk) was initiate...

BACKGROUND We previously reported that IKAS are heterogeneously upregulated in failing rabbit ventricles and play an important role in arrhythmogenesis. This study goal is to test the hypothesis that subtype 2 of the small-conductance Ca(2+) activated K(+) (SK2) channel and apamin-sensitive K(+) currents (IKAS) are upregulated in failing human ventricles. METHODS AND RESULTS We studied 12 nat...

An array of SeaSonde HF radars has been deployed along the Oregon coast by P. M. Kosro of the College of Oceanic and Atmospheric Sciences, OSU. Data from a two-site HF array, which provides measurements of surface currents over a region about 50 km square, have been collected since November 1997. This project is aimed initially at developing and applying, in cooperation with Kosro, methods for ...

The thermal unimolecular dissociation of CH3F was studied in shock waves by monitoring the UV absorption of a dissociation product identified as CH2F. It is concluded that, under conditions applied, the formation of this species corresponds to a minor, spin-allowed, dissociation channel of about 3% yield. Near to the low-pressure limit of the reaction, on the other hand, the energetically more ...

Clayton SC, Haack KK, Zucker IH. Renal denervation modulates angiotensin receptor expression in the renal cortex of rabbits with chronic heart failure. Am J Physiol Renal Physiol 300: F31–F39, 2011. First published October 20, 2010; doi:10.1152/ajprenal.00088.2010.—Excessive sympathetic drive is a hallmark of chronic heart failure (HF). Disease progression can be correlated with plasma norepine...

Excessive weight gain increases systemic inflammation resulting in increased disease risk. Toll-like receptor 4 (TLR4) reportedly mediates increases in inflammation; however, its role in obesity-induced inflammation has not been fully evaluated. The purpose of this study was to determine the longitudinal effect of diet-induced weight gain on blood monocyte concentration and cell-surface TLR4 ex...

pyridostigmine bromide (pb) is a reversible cholinesterase inhibitor. the aim of this study was to determine the effect of orally administration of single dose sustained-released tablet of pyridostigmine bromide (pbsr) on the frequency domain indices of heart rate variability (hrv). thirty-two healthy young men were participated in this study. they were divided into 2 groups; the pyridostigmine...