Background: Depression is a common, under-recognized and under-treated problem that is independently associated with increased morbidity and mortality in patients with chronic kidney disease (CKD). However, there has been a paucity of simple reliable methods to evaluate the severity of depressive symptoms. Recently the 16-item Quick Inventory of Depressive Symptomatology (QIDS), a new measure o...

The autosomal dominant Hailey Hailey disease (HHD) is caused by mutations in the ATP2C1 gene encoding for human secretory pathway Ca2+/Mn2+ ATPase protein (hSPCA1) in the Golgi apparatus. Clinically, HHD presents with erosions and hyperkeratosis predominantly in the intertrigines. Here we report an exome next generation sequencing (NGS) based analysis of ATPase genes in a Greek family with 3 HH...

Abstract Funding Acknowledgements Type of funding sources: None. Background The identification mechanisms in hypertensive heart disease (HHD) that favor the development symptomatic failure (HF) is essential. Little known about role left atrial (LA) mechanical response to exertion this context. Objectives We sought investigate association LA strain parameters exercise with functional capacity an...

HER-2/neu oncoprotein is overexpressed in a variety of human tumors and is associated with aggressive disease. Immunogenic HER-2/neu CTL epitopes have been used as vaccines for the treatment of HER-2/neu positive malignancies with limited success. By applying prediction algorithms for MHC class I ligands and proteosomal cleavages, in this study, we describe the identification of HER-2/neu decam...

BACKGROUND CD8 T cells are thought to play an important role in protective immunity to tuberculosis. The major histocompatibility complex class I subtype HLA-A*0201 is one of the most prevalent class I alleles, with a frequency of over 30% in most populations. HLA-A*0201 transgenic, H-2D(b)/mouse beta2-microglobulin double-knockout mice (HHD) which express human HLA-A*0201 but no mouse class 1,...

Simultaneously increasing the strength and ductility of hot work die steels is significant interest for broad applications. The in-situ development a nano-phase in promising method achieving this objective. However, little success has been reported so far. In study, trace amounts TiC nanoparticles were successfully introduced into high-Cr steel (HHD) through an innovative using nano-TiC/Al mast...

The Helmholtz-Hodge decomposition (HHD) is one of the fundamental theorems of fluids describing the decomposition of a flow field into its divergence-free, curl-free, and harmonic components. Solving for the HHD is intimately connected to the choice of boundary conditions which determine the uniqueness and orthogonality of the decomposition. This article points out that one of the boundary cond...

BACKGROUND Darier disease (DD) and Hailey-Hailey disease (HHD) are autosomal dominantly inherited skin disorders that histologically share the characteristics of suprabasal separation and acantholysis of epidermal keratinocytes. Various mutations in the DD gene (ATP2A2) and the HHD gene (ATP2C1) (respectively encoding the calcium pumps of the sarco/endoplasmic reticulum and the Golgi apparatus)...

The yeast Saccharomyces cerevisiae, with its compact genome and tractable genetics, is a valuable model organism for the heterologous expression of mammalian proteins. In this letter, we show that phenotypic screening in yeast provides insight into the molecular basis of a human disease. Hailey–Hailey disease (HHD), or benign familial pemphigus, is an autosomal dominant intraepidermal blisterin...