We present an image analysis approach as part of a highthroughput microscopy screening system based on cell arrays for the identification of genes involved in Hepatitis C and Dengue virus replication. Our approach comprises: cell nucleus segmentation, quantification of virus replication level in cells, localization of regions with transfected cells, cell classification by infection status, and ...

This paper describes a method of calculating the inherent visibility at all locations in a landscape (‘total viewshed’) by making use of redundant computer cycles. This approach uses a simplified viewshed program that is suitable for use within a distributed environment, in this case managed by the Condor system. Distributing the calculation in this way reduced the calculation time of our examp...

Precision medicine promises to transform cancer treatment in the next decade through the use of high-throughput sequencing and other technologies to identify telltale molecular aberrations that reveal therapeutic vulnerabilities of each patient’s tumor [1]. This session will address the "panomics" of cancer – the complex combination of patient-specific characteristics that drive the development...

(2014). 'From the mole to the molecule': ruthenium catalyzed nitroarene reduction studied with 'bench', high-throughput and single molecule fluorescence techniques.

Advances in molecular and computational technologies have irreversibly changed the course of genetic investigation for almost all organisms. Although “single-gene” and “single investigator” studies will continue to provide detail and resolution to our understanding of biological processes, the greatest impact in this field of investigation will likely come from the high-throughput discovery too...

The principle of this method was to screen the pharmacological activity of six prepared polyphyto formulations by using high throughput screening method for their nootropic action. The study was performed in three stages using one, two and three animals, respectively in a group. Test formulations were given p.o daily at the dose of 50 and 100 mg/kg body weight. The test formulations were compar...

Direct regenerations by using mature cotyledonary node as a explants has been shown to be time-saving and convenient strategy for micropropagation of soybean. So we have evaluated regeneration protocol through single shoot using cotyledonary node as a rapid and efficient protocol for two soybean cultivars and one mutant line. Cotyledonary nodes explants obtained from 7-days-old in vitro</em...

nanotechnology is the engineering of functional systems at the molecular scale which may exert a revolutionary impact on cancer diagnosis and therapy. nanotechnology is being applied to cancer in two broad areas: i) the development of nanovectors such as nanoparticles which can be loaded with drugs or imaging agents and then targeted to tumours, and ii) high-throughput nanosensor devices for de...