The purposc of this study was to determine rhe relationship bctwcen indiyidual difference in me]atonin suppression by cxposure to Light and habitual bedtimc. Seventeen hca]thy male students (mean age: 22,6± 2,4yr) volunteered to participate in the study, The sub.iects were exposcd to light (1OOO lx) for 2 hours from 2 hours befbre the time of pcak salivary meLatonin concentratien. 'two hours af...

In present study an attempt was made to formulate and to evaluate the sustain release Carvedilol matrix tablets by using METHOCEL K100LV CR, METHOCEL K100M CR and Xanthum Gum polymer. The tablets were prepared by direct compression method. The granules were evaluated by angle of repose, bulk density, tapped density and compressibility index, surface P. The formulated tablets were evaluated by w...

Artemisinin (ARMN) is a potent antimalarial drug, which is effective against multidrug resistant strains of Plasmodium falciparum and produces rapid recovery even in patients with cerebral malaria. Being poorly soluble in water, artemisinin is incompletely absorbed after oral intake due to poor dissolution characteristics in the intestinal fluids. To enhance these properties, solid dispersions ...

Fortina P, Higuchi Y, Diamond MA, Wyre DS, Feldman AM. Gene expression profiling during the transition to failure in TNF-alpha over-expressing mice demonstrates the development of autoimmune myocarditis. J Mol Cell Cardiol 2004;36: 515–530. 40. Kubota T, McTiernan CF, Frye CS, Demetris AJ, Feldman AM. Cardiac-specific overexpression of tumor necrosis factor-alpha causes lethal myocarditis in tr...

a sustained-release tablet formulation should ideally have a proper release profile insensitive to moderate changes in tablet hardness that is usually encountered in manufacturing. in this study, matrix aspirin (acetylsalicylic acid) tablets with ethylcellulose (ec), eudragit rs100 (rs), and eudragit s100 (s) were prepared by direct compression. the release behaviors were then studied in two co...

In this study, several examples of hydrogels and nanocomposite hydrogels based on PVP with different content of montmorillonite nanoclay were prepared. Then, the swelling of hydrogels and kinetics of drug delivery of hydrogel in an environment similar to the body (pH 7.4) were examined. The effect of nanoparticle different percentages on the hydrogel was clearly observed. Then kinetics of drug ...

The utilization of natural gum polysaccharides as the vehicle for drug delivery systems and other biomedical applications has increased in recent decades. Their biocompatibility, biodegradability, price are much cheaper than materials. It is also renewable available massive amounts, which main reasons its use pharmaceutical applications. Gum can be easily functionalized with polymers to enhance...

In this study, buccal mucoadhesive tablets of meloxicam were formulated for drug delivery as an alternative route. Direct compression method was applied for the preparation of tablets. Also, different polymers, including hydroxypropyl methyl cellulose (HPMC) 1000, 4000, and 10000, as well as carbopol 934p and carbopol 971p were used as the mucoadhesive polymer and retardant polymer. Thirteen fo...

Working memory serves as a basis for many cognitive functions, including attention, decision-making, and learning. When engaged, it is often associated with an increase in the average neural firing rates across different sensory sensorimotor regions of brain. However, modulation rate extrastriate cortex, involved visual processing, has never been reported during maintenance information. Here, f...