PURPOSE To investigate the prognostic value of ictal scalp EEG patterns in drug-resistant temporal lobe epilepsy associated with hippocampal sclerosis (MTLE-HS) prior to undergoing temporal lobectomy. METHODS Scalp EEGs of the first seizure recorded during presurgical long-term video-EEG monitoring of 284 patients were reviewed. Patients were divided according to seizure laterality as either ...

PURPOSE In patients with left temporal lobe epilepsy (TLE) due to hippocampal sclerosis (HS) decreased naming ability is common, suggesting a critical role for the medial left temporal lobe in this task. We investigated the integrity of language networks with functional MRI (fMRI) in controls and TLE patients. EXPERIMENTAL DESIGN We performed an fMRI verbal fluency paradigm in 22 controls and...

This study investigated the role of underlying pathology on memory function of children with temporal lobe epilepsy (TLE). Memory was assessed in 44 children with TLE resulting from hippocampal sclerosis (HS) or dysembryoplastic neuroepithelial tumours (DNT), and 22 control children. Delayed story and paired associate recall performance was significantly more impaired in children with HS compar...

The present fMRI study explores the cerebral reorganisation of language in patients with temporal lobe epilepsy, according to the age of seizures onset (early or late) and the hippocampal sclerosis (associated or not). Seven right-handed control volunteers and seven preoperative adult epileptic patients performed a rhyme decision (language condition) and a visual detection (control condition) t...

PURPOSE To investigate whether atypical language dominance in epilepsy patients is related to localization and type of lesions. METHODS Four hundred and forty-five epilepsy patients received bilateral Wada testing. Language was classified as left (L), right (R), bilateral-dependent (BD, speech arrest after left and right injections), or bilateral-independent (BI, no speech arrest after either...

OBJECTIVE To determine the frequency and regional involvement of temporal pole signal abnormality (TPA) in patients with hippocampal sclerosis (HS) using fluid-attenuated inversion-recovery (FLAIR) MR imaging, and to correlate this feature with history. METHOD Coronal FLAIR images of the temporal pole were assessed in 120 patients with HS and in 30 normal subjects, to evaluate gray-white matt...

Mesial temporal lobe epilepsy (MTLE) is hypothesized to involve derangement of long-range limbic connectivity, but in vivo evidence is lacking. We used diffusion tractography to investigate the relationship between hippocampal atrophy and connectivity in MTLE patients with hippocampal sclerosis (HS). Atrophy was correlated with relatively decreased connectivity density but increased connectivit...

PURPOSE Semi-quantitative analysis of hippocampal internal architecture (HIA) on MRI has been shown to be a reliable predictor of the side of seizure onset in patients with temporal lobe epilepsy (TLE). In the present study, we investigated the relationship between postoperative seizure outcome and preoperative semi-quantitative measures of HIA. METHODS We determined HIA on high in-plane reso...

Abstract Background Temporal lobe epilepsy is the most common type of focal onset seizure. Focal seizure with impaired awareness, previously known as complex partial (CPS), account for 18–40% all types. Hippocampal sclerosis (HS) cause temporal epilepsy, which produces awareness. It may be detected in MRI visually, but bilateral abnormalities are better identified using volumetric analysis. We ...

AIM To provide information related to atypical language activations (right or bilateral) in positron emission tomography in patients with left clear-cut hippocampal sclerosis. MATERIAL AND METHODS Twelve right-handed patients who had been operated on left-sided hippocampal sclerosis and 12 right-handed normal subjects were included and the synonym generation task was used for evaluation of la...