BACKGROUND Associated anomalies have been reported in around 20% of Hirschsprung patients but many Authors suggested a measure of underestimation. We therefore implemented a prospective observational study on 106 consecutive HSCR patients aimed at defining the percentage of associated anomalies and implementing a personalized and up-to-date diagnostic algorithm. METHODS After Institutional Et...

Background: Parent training is an appropriate way to increase their awareness in dealing with a sick child. Childhood illness causes parents to be worried and stressed. Lack of information about disease will increase their concern. Educational programs can reduce parental stress and postoperative complications. Methods: In this study, the mothers of Hirsc...

AIMS AND OBJECTIVES The aim of this study is to find easier way of home care while obviating the colostomy before single stage pull through operation. MATERIALS AND METHODS From August 2005 to December 2006, eight cases of neonatal Hirschsprung disease were treated. Mean age 4.5 (2-6) day/old with absent anorectal inhibitory reflex, rectosigmiod disease in Barium enema, positive Acetylcholine...

Megacolon is a relatively rare condition appearing in childhood and characterised by obstinate constipation, dilatation of the colon and hypomotility of its wall. It was Yon Ammon who first described megacolon in 1842, fortyfive years before Hirschsprung, though the disease carries the name of the latter. Since then many {etiological factors have been considered, ranging from malnutrition to ne...

We report Down syndrome (DS)-associated congenital gastrointestinal (GI) defects identified during a 15 year, population-based study of the etiology and phenotypic consequences of trisomy 21. Between 1989 and 2004, six sites collected DNA, clinical and epidemiological information on live-born infants with standard trisomy 21 and their parents. We used chi-squared test and logistic regression to...

Highlights:1. All HD patients have good defecation quality after surgery.2. Almost all can control bowel movements without constipation or social problems surgery.3. The most common problem face surgery is soiling, which sometimes requires diapers. AbstractIntroduction: Hirschsprung's disease (HD) a congenital in Meissner and Auerbach's plexus ganglion cells are lost on the distal side of diges...

sertion, and dysgenesis of the iridocorneal angle often leading to glaucoma. Although the exact etiology is unknown, CIE arises from late developmental arrest of the posterior migration of neural crest cells. Likewise, abnormal migration and differentiation of cells derived from the neural crest are implied in IND, a disease of the submucous enteric plexus characterized histologically by a larg...