نتایج جستجو برای: histamine receptor antagonist

تعداد نتایج: 621421  

2013
Junzo Kamei Yuki Nakanishi Megumi Asato Hiroko Ikeda

UNLABELLED BACKGROUND Although the mechanism of fentanyl-induced cough is unclear, several lines of evidence suggest that allergic mediators, such as histamine, may play a role in the production of fentanyl-induced coughs. The aim of this study was to explore the effects of fentanyl on cough sensitivity to inhaled citric acid and on histamine release in BALF in mice. METHODS The cough refl...

Journal: :Pharmacoepidemiology 2023

Proton-pump inhibitors, PPIs, are widely prescribed and available over the counter for prolonged reduction of stomach acid production related disorders. PPIs irreversibly inhibit hydrogen/potassium ATPase in gastric parietal cells. Recent retrospective studies have described an association between PPI use depression. However, there is conflicting evidence that therapy improves depressive sympto...

2011
Zoltan Galajda Jozsef Balla A Jozsef Szentmiklosi Tamas Biro Gabriella Czifra Nora Dobrosi Agnes Cseppento Lajos Patonay Tamas Roszer Gyorgy Balla Laurenciu M Popescu Istvan Lekli Arpad Tosaki

The study has analysed the action of histamine in the rabbit venous system and evaluated its potential role in contraction during increased venous pressure. We have found that a great variety exists in histamine sensitivity and H(1) -histamine receptor expression in various types of rabbit veins. Veins of the extremities (saphenous vein, femoral vein, axillary vein) and abdomen (common iliac ve...

Journal: :Allergology international : official journal of the Japanese Society of Allergology 2014
Yusuke Ohsawa Noriyasu Hirasawa

Histamine plays important roles in inflammation and nervous irritability in allergic disorders, including atopic dermatitis (AD). It has been shown to regulate the expression of pruritic factors, such as nerve growth factor and semaphorin 3A, in skin keratinocytes via histamine H1 receptor (H1R). Furthermore, H1R antagonist reduced the level of IL-31, a cytokine involving the skin barrier and p...

MOHAMMAD H. BOSKABADY , PHILLIP D. SNASHALL,

We have measured the competitive antagonistic effect of chlorpheniramine in bronchi of 8 normal and 12 asthmatic subjects. Classical pharmacological theory states that the degree of competitive antagonism depends only upon 1) antagonist concentration at the receptor, and 2) receptor affinity. Delivery and affinity also influence agonist responsiveness, but measurement of bronchial antagoni...

Journal: :Thorax 1988
M Jordana A D Befus M T Newhouse J Bienenstock J Gauldie

Fibrotic lung tissue shows increased connective tissue deposition and fibroblast proliferation and in addition a substantial increase in mast cell numbers in and around the fibrotic area. To elucidate the question of whether products of mast cells affect the proliferative behaviour of structural cells in the lung and thereby contribute to fibrogenesis, the effect of histamine, a prominent mast ...

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005
Koro Gotoh Koji Fukagawa Tomiyo Fukagawa Hitoshi Noguchi Tetsuya Kakuma Toshiie Sakata Hironobu Yoshimatsu

Glucagon-like peptide-1 (GLP-1), corticotropin-releasing hormone (CRH), and hypothalamic neuronal histamine suppress food intake, a target of leptin action in the brain. This study examined the interactions of GLP-1, CRH, and histamine downstream from the leptin-signaling pathway in regulating feeding behavior. Infusion of GLP-1 into the third cerebral ventricle (i3vt) at a dose of 1 mug signif...

Journal: :The Journal of biological chemistry 1992
Y Cherifi C Pigeon M Le Romancer A Bado F Reyl-Desmars M J Lewin

The histamine H3 receptor agonist (R)alpha-methylhistamine (MeHA) inhibited, in a nanomolar range, basal and carbachol-stimulated inositol phosphate formation in the human gastric tumoral cell line HGT1-clone 6. The inhibition was reversed by micromolar concentrations of the histamine H3 receptor antagonist thioperamide and was sensitive to cholera or pertussis toxin treatment. Using [3H]N alph...

Journal: :Molecular pharmacology 1998
V Boss X Wang L F Koppelman K Xu T J Murphy

The nuclear factor of activated T cells (NFAT) mediates a cyclosporin A (CsA)- and FK506-suppressible transcriptional program in lymphocytes after antigen-stimulated phospholipase C activation. Nonlymphoid cells also express NFAT isoforms, raising the possibility that these isoforms can be regulated by other extracellular stimuli. This study sought to determine whether histamine can trigger NFA...

2012
Kirti Patel Kalpana Patel Tejas Mehta Tejal Gandhi

Plan: The present study was undertaken to investigate the H2 receptor antagonistic action of fresh juice of Brassica oleracea var. capitata Methodology: Two sets of experiments consisted of recording the responses of the uterine horn preparations (precontracted with potassium chloride, KCl) to histamine (4.5; 9; 17.99; 35.99; 71.98 × 10 and 14.40× 10 mol/L, 2 minute each concentration) in absen...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید