Background: Methotrexate (MTX) is used as an antineoplastic drug in the treatment of various cancers and non-cancerous diseases. Ovarian ablation is considered to be effective in delaying recurrence of cancer and increasing survival in young women. When added to chemotherapy, it is less clear that this technique is effective. Uniqueness of the present study is that we used ovariectomized (OVX) ...

This study investigated the neurohistological effect of lead acetate on cerebellar cortex adult wistar rats. Lead is a common industrial poisonous substance that its prevalence in environment exhibits toxic which makes different organs & tissues especially central nervous system vulnerable to exposure. however, found useful applications diverse items daily needs like paints, water pipes, ca...

•Chronic lead acetate toxicity was induced in male rats by oral administration.•Effect of Ocimum gratissimum on the cerebellum.•Oral administration led to oxidative stress cerebellum.•Ocimum extract attenuated and enhanced antioxidant enzymes.•Ocimum ameliorated acetate-induced cerebellum. ObjectivesLead (LA) is a known toxicant, its exposure environment has been increase recent times, leading ...

Urtica dioica has been known as a plant that decreases blood glucose. Despite the importance of this plant in herbal medicine, relatively little research has been down on effects of this plant on islets yet. The objective of the current study was to evaluate the effect of dried Urtica dioica leaf alcoholic and aqueous extracts on the number and the diameter of the islets and histological parame...

Preputial gland is one of the prime sources of pheromones in rats. The study on pheromone identification in preputial gland is well established in laboratory rat, house rat and voles. But the study was lacking in the preputial gland of bandicoot rats. Hence, the present investigation was aimed to identify the volatile and protein profiles of preputial gland of male bandicoot rat. Gas chromatogr...

Abstract Background Social isolation rearing (SIR) is a developmental schizophrenia model with characteristic behavioral symptoms like anxiety and olfactory deficits influenced by the amygdala bulbs respectively. Psychiatric disorders dementias are often comorbid, neuropsychiatric disturbances constituting inherent component of Alzheimer’s. As long‐term side effects mar available antipsychotics...

Salinomycin is used as an antibiotic in animal husbandry. Its implication in cancer therapy has recently been proposed. Present study evaluated the toxic effects of Salinomycin on male reproductive system of mice. Doses of 1, 3 or 5 mg/kg of Salinomycin were administered daily for 28 days. Half of the mice were sacrificed after 24 h of the last treatment and other half were sacrificed 28 days a...