INTRODUCTION Current grading system in application by WHO/ISUP divides urothelial malignancies in low and high grade by morphologic criteria while strict segregation may become cumbersome in limited tissue specimens. As grading these carcinomas are of utmost prognostic significance after depth of invasion, therefore we evaluated the role of immunohistochemical expression of p53 and cytokeratin ...

BACKGROUND We proposed a new grading and staging system for primary biliary cirrhosis (PBC), which takes into account the degree of both chronic cholangitis activity (CA) and hepatitic activity (HA) for grading disease activity and that of fibrosis, bile duct loss, and chronic cholestasis for staging. In this study, we validated our new system. METHODS Using liver biopsy specimens from 166 ca...

In a previous editorial, we criticized pathological complete response (pCR) as an endpoint in rectal cancer after neoadjuvant chemoradiation, because only a small proportion of patients (10–20%) are captured by a pCR. We also pointed out the confusion as to what constitutes a pCR: ypT0 alone, ypT0 plus ypTmic, or ypT0 plus ypN0. Further confusion arises from authors who define a pCR as ‘‘the pr...

OBJECTIVE The purposes of this study were to histologically assess different types of oral squamous cell carcinoma and the silver-binding nucleolar organizer region (AgNOR) morphology in neoplastic cells, as well as to quantify the number of AgNORs in each type of carcinoma in order to relate AgNOR count and histologic grading. MATERIAL AND METHODS Twenty-eight cases of oral squamous cell car...

BACKGROUND AND PURPOSE The WEB Occlusion Score has been proposed to assess angiographic outcomes for intracranial aneurysms treated with the Woven EndoBridge (WEB) device. Using a large series of experimental aneurysms treated with the WEB, we had the following objectives: 1) to compare angiographic outcomes as measured by the WEB Occlusion Scale with histologic results, and 2) to assess intero...

CONTEXT The Gleason grading system is one of the most powerful predictors of outcome in prostate cancer and a cornerstone in counseling and treating patients. Since its inception, it has undergone several modifications triggered by a change in clinical practice and a better understanding of the cancer's histologic spectrum and variants and their prognostic significance. OBJECTIVE To provide a...

BACKGROUND The decision to proceed with elective neck dissection (END) is based on the probability of finding microscopic disease in a patient without clinical evidence of lymph node metastases. In contrast to squamous cell carcinoma of the head and neck, there is currently no standard of care for END in salivary gland carcinoma. This is due in large part to the relatively low incidence of thes...

Histologic grading in breast cancer is based on the evaluation of 3 morphologic features (tubule formation, nuclear pleomorphism and mitotic count), is essentially describing proliferation and differentiation in breast cancer, and is considered an important prognostic factor for this disease. It has been suggested that histologic grade 1 and 3 breast tumors are 2 different diseases that may hav...

OBJECTIVES To correlate urologists' impressions of the tumor grade of upper tract tumors at ureteroscopy with the histologic findings after biopsy or resection. METHODS A retrospective review of all patients who underwent diagnostic or therapeutic ureteroscopy for upper tract transitional cell carcinoma (TCC) between 1992 and 2002 was performed. Only patients who had proven TCC with a descrip...