Atrial fibrillation (AF) is one of the major health risks for strokes, and has been found to increase the risk of ischemic stroke fivefold (Wolf et al., 1987). Strokes with AF are more severe, cause greater disability and have worse outcomes than those without (Jørgensen et al., 1996; Lin et al., 1996). Approximately 15–20% of all strokes are due to AF but the percentage increases up to 40% for...

Introduction We studied the reliability of a new ST-segment analysis on a 24-hour 12-lead holter recording comparing ST-depression during exercise testing with active molsidomine and placebo drugs in a randomized, double-blind, crossover, clinical trial. Methods and results 35 patients with proven coronary heart disease received either 4 mg regular molsidomine, 8 mg molsidomine SR (Sustained Re...

A potential reduction in symptoms related to atrial fibrillation after treatment of gastroesophageal reflux disease symptoms with proton pump inhibitor therapy has been previously described. However, illustration of this relationship by combined 24-hour pH and ambulatory Holter monitoring has not been performed. We report 3 patients with symptoms of both palpitations and reflux who underwent si...

AIMS Current treatment may have changed the risk profiles of survivors of acute myocardial infarction (AMI). We evaluated the utility of Holter-based risk variables in the prediction of sudden cardiac death (SCD) among survivors of AMI treated with modern therapy. METHODS AND RESULTS A total of 2130 AMI patients (mean age 59 +/- 10 years) were included. The patients were treated with modern t...

BACKGROUND Continuous 12-lead ECG monitoring (Holter) in early-phase pharmaceutical studies is today widely used as an ideal platform to extract discrete ECGs for analysis. The extraction process is typically performed manually by trained readers using commercial Holter processing systems. METHODS Antares, a novel method for automatic 12-lead extraction from continuous Holter recordings apply...

OBJECTIVE This study was conducted to evaluate the effect of apremilast and its major metabolites on the placebocorrected change-from-baseline QTc interval of an electrocardiogram (ECG). MATERIALS AND METHODS Healthy male subjects received each of 4 treatments in a randomized, crossover manner. In the 2 active treatment periods, apremilast 30 mg (therapeutic exposure) or 50 mg (supratherapeut...

The primary goal of long-term monitoring is the improvement of diagnostic yield. Despite the clear utility of Holter monitoring in clinical cardiology, issues of relatively low diagnostic yield, cost and inconvenience have motivated the development of ultra-portable devices referred to as ECG patch monitors. Although the "gold standard" for assessing cardiac rhythm abnormalities remains a 12-le...

Continuous recording of cardiac rhythm over a period of 24-48 hour non-invasively using a digital device and subsequent computer software assisted electrocardiographic analysis (Holter ECg monitoring) plays a significant clinical role in the evaluation of arythmias in subjects with palpitations, subjective chest discomfort, as well as for evaluation of syncope. Holter electrocardiogram is also ...

BACKGROUND Patients with retinal vascular occlusion disease have an increased risk for ischemic stroke and share some risk factors with cerebrovascular disease. The purpose of this study was to analyze the prevalence of atrial fibrillation (AF) in subjects with retinal vascular occlusive disease and anterior ischemic optic neuropathy and to compare these data to an ischemic stroke group. METH...