OBJECTIVE Several cutoff points of the homeostasis model assessment of insulin resistance (HOMA-IR; varying from 2.5 to 4.0) have been suggested for diagnosing IR in youth. In this study, we determined the distribution of the HOMA-IR in Mexican children and adolescents. DESIGN AND METHODS A total of 6132 children and adolescents from San Luis Potosi, León, Queretaro, and Durango, which are ci...

BACKGROUND Homeostasis model assessment of insulin resistance (HOMA-IR) is a surrogate estimate of directly measured insulin resistance that been robustly proven to be associated with diabetes and cardiovascular disease. The purpose of this study was to evaluate the use of several simple indicators to identify postmenopausal women with insulin resistance estimated by HOMA-IR. METHODS We recru...

The point-counterpoint articles in the September issue of Diabetes Care (1,2) raise several interesting issues on our understanding of insulin resistance, homeostasis model assessment (HOMA), and the future of measurement shortcuts for insulin resistance and secretion. McAuley et al. (1) provide an overview of methods to assess insulin sensitivity and secretion. The conditional nature of the ti...

Materials and methods: A total of 64 obese subjects with NAFLD (13.5 ± 1.36 years of age, 34 male) and 32 ageand gender-matched control subjects (13.8 ± 1.24 years of age, 16 male) were enrolled in the study. All subjects underwent a physical examination, laboratory tests, and ultrasonographic and Doppler examinations of the liver. The homeostasis model assessment of IR (HOMA-IR) was used for t...

It is well known that abdominal obesity, dyslipidemia, and insulin resistance are highly prevalent in patients receiving maintenance treatment with antipsychotics, but there is limited knowledge about the association between cardiovascular risk factors and treatment with antipsychotic drugs. In this naturalistic study we investigated a sample of 809 antipsychotic-treated patients from Swedish p...

OBJECTIVE Exposure to acrylamide in foodstuffs and smoking has become a worldwide concern. The effect of acrylamide on glucose homeostasis is not known. The goal of the present study was to test the hypothesis that trace acrylamide exposure might be independently associated with both reduced blood insulin and reduced insulin resistance. RESEARCH DESIGN AND METHODS We examined 1,356 participan...