Heart failure has become a worldwide epidemic of the 21st century with increasing impact on healthcare systems. The 2012 ESC and 2013 ACCF/AHA guidelines have set the stage for current therapy to reduce mortality and morbidity. There is a dawn of hope for therapy of acute and diastolic heart failure; it has become clearer that patients benefit from mitral reconstruction and which patients benef...

Researchers and clinicians are constantly striving to find new, more effective ways of treating cancer. As a hopeful world looks for the miracle that will cure cancer once and for all, a major revolution in cancer treatment has been quietly taking place in radiation oncology—a revolution that many consider has involved greater, more significant change within the past five years than the field h...

Pulmonary arterial hypertension (PAH) is a progressive disease characterized by pulmonary vascular remodeling and right heart failure. In its advanced stage, PAH demonstrates muscularization of distal pulmonary arterioles, concentric thickening, and obstruction of vascular lumen due to the proliferation of pulmonary artery endothelial cells (PAECs) and pulmonary artery smooth muscle cells (PASM...