Thyrotropin (TSH) is the prime regulator of thyroid cell growth and function and acts through the thyrotropin receptor (TSHR) located on the surface membrane of thyrocytes. Somatic heterozygous mutations that cause TSHR activation in the absence of TSH have been found in toxic adenomas and in hot nodules of multinodular goiters. Clinically and histologically heterogeneous nodules can share comm...

Although fine-needle aspiration cytology is considered to be the reference method for evaluating thyroid nodules, the results are inaccurate in approximately 10-30% of cases. Several studies have attempted to predict the risk of malignancy in thyroid nodules based on age, nodularity, thyrotropin values, thyroid autoimmune disease, hot/cold nodule status, and ultrasound parameters. However, no c...

Background: Clinically solitary thyroid nodule may be defined as a goitre which on clinical examination appears to be a single nodule in an otherwise normal gland. In reality, solitary thyroid nodule is not a single disease process but a constellation of processes encountered in a variety of clinical diseases such as dominant nodule of a multi nodular goitre, true adenoma, malignancy, thyroidit...

Correspondence: Dr Alper, Orkide Apt D: 9 No 17, Idealtepe/Maltepe, Istanbul/Turkey. Fax: +90 216 4899587, e-mail: [email protected] or [email protected]. tectable on both initial and repeat tests, although T3 and T4 were not grossly elevated, consistent with the diagnosis of subclinical hyperthyroidism [TSH = 0.02 μU/ml (normal = 0.35–4.94 μU/ml); free T3 = 75 ng/dl (normal = 60–181 ng/dl)...

prevalence of thyroid nodules diagnosed by ultrasonography has been reported to be high (about 50%) probably due to iodine deficiency in our region. most thyroid nodules benign but some require treatment for cosmetic reasons or subjective symptoms. the conventional method of treatment in iran is surgery. for the first time in iran, from february 2016, 50 patients with 63 nodules (solid or cysti...

This is a retrospective study on clinical course and treatment response of patients with thyroid hot nodule, referred to nuclear medicine department of Shariati Hospital from 1360 to 1377. From the total 58 patients with average age of 43 yr and incidence peak of 40 yr, 81% were female and 19% were male. 64% of the patients were thyrotoxic and 36% were euthyroid at presentation. Thyrotoxi...

Background: Local ablative treatments play an important role for patients who cannot be treated surgically. Radiofrequency ablation is a well-established alternative to surgical treatment of thyroid nodules, however it also has disadvantages. Microwave ablation (MWA) is a new minimally invasive treatment promising several improvements. The aim of this retrospective study was to evaluate the eff...

Introduction: Extraosseous accumulation of 99mTc – methylene diphosphonate (MDP) may be due to neoplastic, dystrophic, hormonal, inflammatory, ischemic, traumatic or excretory disorders. 99mTc-MDP incidental thyroid uptake is not frequent and is possibly caused by the presence of dystrophic or metastatic calcification, biopsy procedure and presence of beni...

OBJECTIVE The controversy that iodized salt may increase the risk of thyroid disorders has been aroused in China during the past decade. Most of studies focused on adult rather than children. We aimed to explore whether iodized salt was associated with an increased risk of thyroid nodule in Chinese children. METHODS The cross-sectional study was conducted in Hangzhou, China, in 2010. Iodized ...

this is a retrospective study on clinical course and treatment response of patients with thyroid hot nodule, referred to nuclear medicine department of shariati hospital from 1360 to 1377. from the total 58 patients with average age of 43 yr and incidence peak of 40 yr, 81% were female and 19% were male. 64% of the patients were thyrotoxic and 36% were euthyroid at presentation. thyrotoxic symp...