The interactions between photodynamic therapy (PDT) with hemotoporphyrin derivative (HPD) and treatment with cytotoxic drugs have been examined using both an in vitro tissue culture assay and an in vivo transplantable mouse tumor assay. Adriamycin (0.5-4.0 mg/kg) administered with HPD and at the time of irradiation potentiated the photodynamic effect, doubling the duration of tumor control. Adr...

A comparison study of the effects of hematoporphyrin deriv ative (HPD) photoradiation therapy on two different mouse sar coma tumor model systems (RIF-1 + EMT-6) was performed. Twenty-four h after i.v. administration of HPD, the responses to total laser light doses of 50-400 J/cm2 were evaluated by histological examination and the uptake and distribution of HPD using a computer enhanced digital...

Abstract Background Immune checkpoint blockades (ICBs) are characterized by a durable clinical response and better tolerability in patients with variety of advanced solid tumors. However, we not infrequently encounter hyperprogressive disease (HPD) exhibiting paradoxically accelerated tumor growth poor outcomes. This study aimed to investigate implications factors immune cell composition on dif...

Tyrosinemia type 1, caused by mutations in the fumarylacetoacetate hydrolase gene (Fah), is characterized by severe liver injury. We earlier developed a tyrosinemic mouse model with two genetic defects, Fah and 4-hydroxyphenylpyruvate dioxygenase (Hpd) deficiencies. Apoptosis of hepatocytes was induced and an acute onset of liver failure occurred after administration of homogentisic acid (HGA),...

Hearing protection devices (HPDs) play a significant role in protecting workers from occupational noise-induced hearing loss. Individual HPD fit-testing estimates the amount of protection, or attenuation, that an individual achieves from a given HPD as it is worn. Results from a single fit-test may not be representative of real-world HPD performance over time, however, due to inconsistency in h...

CD36 is a ubiquitous membrane glycoprotein that binds long-chain fatty acids. The presence of a functional CD36 is required for the induction of satiety by a lipid load and its role as a lipid receptor driving cellular signal has recently been demonstrated. Our project aimed to further explore the role of intestinal CD36 in the regulation of food intake. Duodenal infusions of vehicle or sulfo-N...

The mechanism by which replacement of some dietary carbohydrates with protein during weight loss favors lipid metabolism remains obscure. In this study, we investigated the effect of an energy-restricted, high-protein/low-carbohydrate diet on lipid metabolism in obese rats. High-sucrose-induced obese rats were assigned randomly to one of two energy-restricted dietary interventions: a carbohydra...

A comparison study of the effects of hematoporphyrin derivative (HPD) photoradiation therapy on two different mouse sarcoma tumor model systems (RIF-1 + EMT-6) was performed. Twenty-four h after i.v. administration of HPD, the responses to total laser light doses of 50-400 J/cm2 were evaluated by histological examination and the uptake and distribution of HPD using a computer enhanced digital v...

In this paper we compare the performance of static and adaptive provisioning methods with ns2-simulations. In the simulations we use a topology that captures the most fundamental aspects of real networks: multiple bottleneck links, paths with low and high delay, cross traffic, bidirectional traffic etc. We also use a representative traffic mix consisting of five different traffic types: FTP, HT...