BACKGROUND Drugs that prolong the heart rate corrected QT interval (QTc) on the electrocardiogram (ECG) by blocking the hERG potassium channel and also block inward currents (late sodium or L-type calcium) are not associated with torsade de pointes (e.g. ranolazine and verapamil). Thus, identifying ECG signs of late sodium current block could aid in the determination of proarrhythmic risk for n...

Congenital insensitivity to pain with anhidrosis (CIPA) is a very rare hereditary syndrome worldwide due to certain gene mutations and histological appearances that affect the peripheral pathway of noxious stimuli transmission and the innervation of sweat glands. It is characterized by insensitivity to pain, anhidrosis, and heat intolerance. We describe the clinical features and the anaesthetic...

objective(s) extracellular matrix (ecm) and basement membrane (bm) play important roles in many developmental processes during development and after birth. among the components of the bm, collagen fibers specially type iv are the most important parts. the aim of this study was to determine the time when collagen type iv appears in the bm of lens structure during mouse embryonic development. mat...

in this case report, we described a 74-year-old female patient with major complaint of respiratory problemsdyspnea after meal. chest x-ray of the patient revealed a  gianttype iv hiatal hernia. preoperative evaluations of the patient included esophagoscopy, esophageal manometry, barium swallow, and ct-scan. repair of the hernia was performed using a dual mesh on the diaphragm and partial anteri...

Hereditary sensory neuropathy type I (HSN I) is a slowly progressive neurological disorder characterised by prominent predominantly distal sensory loss, autonomic disturbances, autosomal dominant inheritance, and juvenile or adulthood disease onset. The exact prevalence is unknown, but is estimated as very low. Disease onset varies between the 2nd and 5th decade of life. The main clinical featu...

In this case report, we described a 74-year-old female patient with major complaint of respiratory problemsdyspnea after meal. Chest X-ray of the patient revealed a  gianttype IV hiatal hernia. Preoperative evaluations of the patient included esophagoscopy, esophageal manometry, barium swallow, and CT-scan. Repair of the hernia was performed using a dual mesh on the diaphragm and partial anteri...

Stochastic activity networks (SANs) are a powerful and flexible extension of Petri nets. These models can be used for the modelling and analysis of various kinds and different aspects of distributed real-time systems. Similar to other classical extensions of Petri nets, SANs have some limitations for modelling complex and large-scale systems. In order to remove some of these limitations and pro...

Enamel mineralization is affected by genetic disorders like Down syndrome and familial dysautonomia (FD). Congenital Insensitivity to Pain with Anhidrosis (CIPA) is associated with decreased sensation and autonomic dysfunction, somehow similar to FD. In this study we examined the effect of CIPA on pre and post-natal enamel mineralization of 9 primary extracted teeth and matchpaired normal teeth...

BACKGROUND The current proarrhythmia safety testing paradigm, although highly efficient in preventing new torsadogenic drugs from entering the market, has important limitations that can restrict the development and use of valuable new therapeutics. The CiPA (Comprehensive in vitro Proarrhythmia Assay) proposes to overcome these limitations by evaluating drug effects on multiple cardiac ion chan...