Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are neurotropic viruses and common human pathogens causing a major public health problem such as genital herpes, a sexually transmitted disease also correlated to increased transmission and replication of the human immunodeficiency virus type-1 (HIV-1). Therefore, compounds capable of blocking HIV-1, HSV-1 and HSV-2 transmission represent c...

Herpes simplex virus type 1 (HSV-1) and HSV-2 are neurotropic viruses and common human pathogens causing major public health problems such as genital herpes, a sexually transmitted disease also correlated with increased transmission and replication of human immunodeficiency virus type 1 (HIV-1). Therefore, compounds capable of blocking HIV-1, HSV-1, and HSV-2 transmission represent candidate mi...

It is often stated that individuals of a species can differ significantly in their innate resistance to infection with herpes simplex virus type 1 (HSV-1). Three decades ago Lopez reported that C57BL/6 mice could survive a 5,000-fold-higher inoculum of HSV-1 given intraperitoneally than mice of the A or BALB/c strain (Nature 258:152-153, 1975). Susceptible strains of mice died of encephalitis-l...

OBJECTIVES To explore epidemiological evidence about the interaction of herpes simplex virus (HSV) 1 and HSV-2 infections. METHODS A systematic review was undertaken of published epidemiological studies describing the pattern of HSV-1 or HSV-2 by age, and the coincidence of the two viral infections. RESULTS In cross sectional studies the unadjusted odds of HSV-2 are greater in those with HS...

OBJECTIVES To determine the proportion of herpes simplex virus type 1 (HSV-1) and HSV type 2 (HSV-2) in first episodes of genital herpes. To evaluate the use of HSV specific serology for classifying first episodes of genital herpes and for defining HSV serostatus in the patients' sexual partners. METHODS 108 consecutive patients with first episodes of genital herpes seen at three STD clinics ...

this study investigated the association between hsv-1 infection and atopy by comparing seropositivity to hsv-1 in atopic children with asthma and allergic rhinitis and in non-atopic children. totally 249 children randomly selected from the university outpatient pediatric clinics were prospectively enrolled in the study between september 1 and november 30, 2007. serum samples were examined using...

Interaction of Herpes Simplex Virus (HSV) glycoprotein D (gD) with the host cell surface during Chlamydia trachomatis/HSV co-infection stimulates chlamydiae to become persistent. During viral entry, gD interacts with one of 4 host co-receptors: HVEM (herpes virus entry mediator), nectin-1, nectin-2 and 3-O-sulfated heparan sulfate. HVEM and nectin-1 are high-affinity entry receptors for both HS...

background: cumin ( cuminum cyminum l . [family apiaceae]) seed essential oil is reported to have antiseptic activity. until now the antiviral properties of cumin seed extracts on viruses such as herpes simplex virus-1 (hsv-1) have not been studied. the objective of this study was to investigate the in vitro effects of aqueous, methanolic and hydroalcoholic extracts of cumin seed on hsv-1 growt...

Genital herpes is a major risk factor in acquiring human immunodeficiency virus type-1 (HIV-1) infection and is caused by both Herpes Simplex virus type 1 (HSV-1) and HSV-2. The amphipathic peptide C5A, derived from the non-structural hepatitis C virus (HCV) protein 5A, was shown to prevent HIV-1 infection but neither influenza nor vesicular stomatitis virus infections. Here we investigated the...