The US Environmental Protection Agency Endocrine Disruptor Screening Program (EDSP) is a tiered screening approach to determine the potential for a chemical to interact with estrogen, androgen, or thyroid hormone systems and/or perturb steroidogenesis. Use of high-throughput screening (HTS) to predict hazard and exposure is shifting the EDSP approach to (1) prioritization of chemicals for furth...

This paper reports results of the test of HTS conductor manufactured by Intermagnetics General Corporation (IGC). The HTS version of the CESR dual bore quadrupole magnet has been analyzed using data obtained in this test. 1 HTS test The main purpose of the experiments described below was to obtain HTS characteristics needed for magnet design. The prime goal was to measure the HTS performance de...

A heuristic algorithm was developed to maximize compound diversity within a subset of screening plates used in high throughput screening (HTS) to initiate the drug discovery process. The approach overcame the challenge of combinatorial explosion for selecting plate subsets with maximum compound diversity. The method yielded novel forms of plate-based diversity subsets (PBDS) for HTS screening i...

BACKGROUND Analyses of substrate and metabolites are often bottleneck activities in high-throughput screening of microbial bioprocesses. We have assessed Fourier transform infrared spectroscopy (FTIR), in combination with high throughput micro-bioreactors and multivariate statistical analyses, for analysis of metabolites in high-throughput screening of microbial bioprocesses. In our previous st...

Over the years a massive amount of high-throughput screening (HTS) data has been collected, however, the data are mainly utilized for providing lead generation programs with chemical entry points. The comparison of molecular structures and HTS data across many projects allows to identify and validate structural patterns of frequent hitters, i.e. compounds which generate multiple hits in various...

New high-throughput DNA sequencing (HTS) technologies developed in the past decade have begun to be applied to the study of the complex gene rearrangements that encode human antibodies. This article first reviews the genetic features of Ig loci and the HTS technologies that have been applied to human repertoire studies, then discusses key choices for experimental design and data analysis in the...

Previous studies on HTS coils can be put into two categories: tape surface coils and thin-film surface coils[1-4]. In this study, we build a whole new Bi2Sr2Ca2Cu2O3 (Bi-2223) superconducting volume coil (length of 8 cm) designed for the mice whole body imaging at Bruker 3T MRI system. The HTS volume coil has 2.3 folds higher S/N than that of the HTS volume coil at 300K for the mice body screen...

High-Throughput Screening (HTS) is widely used in the pharmaceutical industry to identify novel chemical starting points for drug discovery projects. The current study focuses on the relationship between molecular HTS hit rate and four common molecular descriptors: molecular lipophilicity (as described by ClogP), size (heavy atom count, HEV), degree of aromaticity content (Fsp3) and fraction of...

We report details on the quenching incident of an 18 T high-temperature superconducting (HTS) magnet, which occurred in December 2020. It has been received that no-insulation (NI) design HTS magnet is relatively safe quenching. However, NI could not completely prevent from and damaging associated system. Due to significant vibrations fast energy dissipation during quenching, detector components...