Multicentric Castleman’s disease (MCD) is a rare systemic lymphoproliferative disorder characterised by polylymphadenopathy, B-symptoms and classical lymph node histological findings. Hypercytokinemia, particularly interleukin-6 (IL-6), secondary to human herpes virus-8 (HHV-8) infection is key to the pathogenesis of MCD. However, MCD can occur independent of HHV-8 an entity known as idiopathic...

Background Kaposi’s sarcoma (KS) is a tumor derived from the endothelial cell lineage caused by Kaposi sarcomaassociated virus (KSHV), also known as human herpes virus 8 (HHV-8). Four subtypes of KS have been described: classical KS, African endemic KS, immunosuppression-associated KS and AIDS-associated KS. Over 95% of the lesions have been found to be infected with HHV-8, regardless of the cl...

Plasmablastic lymphoma (PBL) of the oral cavity is an acquired immunodeficiency syndrome-related lymphoma. The immunophenotype of this disease is associated with poor expression of B-cell markers but a positive reactivity for plasma cell markers. PBL is highly aggressive and responds poorly to treatment. Although originally described in the oral cavity, this disease can occur in other body nich...

Multicentric Castleman’s disease (MCD) is a rare systemic lymphoproliferative disorder characterised by polylymphadenopathy, B-symptoms and classical lymph node histological findings. Hypercytokinemia, particularly interleukin-6 (IL-6), secondary to human herpes virus-8 (HHV-8) infection is key to the pathogenesis of MCD. However, MCD can occur independent of HHV-8 an entity known as idiopathic...

Kaposi's sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8, is a newly identified virus with tumorigenic potential. Here, we cloned and expressed the DNA polymerase (Pol-8) of KSHV and its processivity factor (PF-8). Pol-8 bound specifically to PF-8 in vitro. Moreover, the DNA synthesis activity of Pol-8 was shown in vitro to be strongly dependent on PF-8. Addition of PF-8 to Pol-8 ...

Abstract To circumvent time-consuming clinical trials, testing whether existing drugs are effective inhibitors of SARS-CoV-2, has led to the discovery Remdesivir. We decided follow this path and screened approved medications "off-label" against SARS-CoV-2. Fluoxetine inhibited SARS-CoV-2 at a concentration 0.8 µg/ml significantly in these screenings, EC50 was determined with 387 ng/ml. Furtherm...

Abstract Background Primary effusion lymphoma is a rare, aggressive large B-cell strictly linked to infection by Human Herpes virus 8/Kaposi sarcoma-associated herpes virus. In its classic form, it characterized body cavities neoplastic effusions without detectable tumor masses. It often occurs in immunocompromised patients, such as HIV-positive individuals. may affect HIV-negative elderly pati...

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