PURPOSE Aromatase inhibitors (AIs) have been recently associated with hip fractures. We present a case series of breast cancer survivors and a systematic review of bone health care in breast cancer. EXPERIMENTAL DESIGN We completed clinical assessments and bone density testing (BMD) of hip fractures from January 2005 to December 2008. Prefracture and 12-month functional status was obtained. S...

OBJECTIVES The aim of this study was to investigate whether bone alterations detected by hip magnetic resonance imaging (MRI) were associated with subsequent primary hip OA. METHODS We enrolled 7 patients with hip joint pain from their first visit, at which hip joints were classified as grade 0 or I on the Kellgren-Lawrence grading scale. Plain radiographs and magnetic resonance imaging (MRI)...

BACKGROUND Peripheral arterial disease (PAD) and osteoporosis are chronic illnesses that increase in prevalence with aging and certain metabolic disorders. The association between PAD, rates of bone loss, and fracture risk in older men is uncertain. METHODS AND RESULTS We sought to test the hypothesis that PAD is associated with higher rates of bone loss and increased fracture risk. We analyz...

To determine whether plain radiographs accurately represent the true cement-bone interlock, a comparison was made between radiographs and macroscopic morphology on cross sections of 11 human femora into which a cemented endoprosthesis had been inserted. Four femora had been retrieved postmortem from patients with a hip arthroplasty, and seven cadaver femora were cemented under varying condition...

Osteoporosis is characterized by low bone mass and micro architectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture. It has been difficult to attribute bone loss in aging men to either testosterone or estrogen deficiency. 179 apparently healthy South Indian men in the age group of 40-80 yrs were studied. Body Mass Index (BMI), Bone Mi...

BACKGROUND Fat mass is variably associated with bone mass, possibly due to differential mechanical and biological effects of fat mass. We examined the association of fat mass with bone mass in a lean population. OBJECTIVE To investigate association between hip bone mineral density and fat and lean mass in a cross-sectional study from southern India. DESIGN The Andhra Pradesh Children and Pa...

INTRODUCTION In case of severe post-tuberculosis osteoarthritis of the hip, arthrodesis, excision arthroplasty, or total hip arthroplasty may be considered. The latter can be challenging, because destruction of the joint, and most importantly the acetabulum, is frequently seen. To fill up acetabular bone stock loss during total hip arthroplasty, there is the possibility to use bone auto-grafts ...

Whole-body vibration (WBV) has been shown to be osteogenic in animal models; however, its application in humans is not clear. The purpose of this study was to examine the effects of an 8-month program involving WBV plus resistance training on bone mineral density (BMD) and bone metabolism in older postmenopausal women. Fifty-five estrogen-deficient postmenopausal women were assigned to a resist...

BACKGROUND Individuals with osteoporosis are predisposed to hip fracture during trips, stumbles or falls, but half of all hip fractures occur in those without generalised osteoporosis. By analysing ordinary clinical CT scans using a novel cortical thickness mapping technique, we discovered patches of markedly thinner bone at fracture-prone regions in the femurs of women with acute hip fracture ...

Denosumab is a human monoclonal antibody which specifically blocks receptor activator of nuclear factor κB ligand and is a very potent antiresorptive drug. Its efficacy in reducing the risk of vertebral, hip and nonskeletal fracture has been proven in a large prospective, randomized multicenter study of 7808 postmenopausal women with osteoporosis [Fracture Reduction Evaluation of Denosumab in O...