Tuberculosis is a disease caused by Mycobacterium tuberculosis, representing the second leading cause of death an infectious agent worldwide. The available vaccine against this has insufficient coverage and variable efficacy, accounting for high number cases In fact, estimated third world’s population latent infection. Therefore, developing new vaccines crucial to preventing it. study, highly a...

Background: Pediatric bronchial asthma is associated with considerable morbidity. The study was carried out to examine the association of Human Leukocyte Antigen (HLA)- Class II with the disease as we found no similar study on Asian Indian population. Objective: To define the HLA-Class II antigens in Asian Indian pediatric patients with asthma. Methods: A total of 103 children with asthma and 1...

A proposal for a standardized nomenclature for human leukocyte antigen (HLA) microsatellites is presented. It provides recommendations for Microsatellites as regards to locus name, primer names, and denominations for alleles.

Submit Manuscript | http://medcraveonline.com Abbreviations: AM: Amniotic Membrane; MO: Moringa Oleifera; ITBBR: Institute of Tissue Banking and Biomaterial Research; VEGF: Vascular Endothelial Growth Factor; HGF: Hepatocyte Growth Factor; TGF: Transforming Growth Factor; HLA: Human Leukocyte Antigen; DR: Differential Regulation; MSC: Mesenchymal Stem Cells; SLPI: Secretary Leukocyte Proteinase...

Detection of circulating antibodies directed against human leukocyte antigen (HLA) molecules, which corresponds to the current definition ‘sensitized patient’, has been shown have a severe impact on both access transplantation and, if anti-HLA are specific selected donor, survival graft. However, not all donor-specific (DSA) equally harmful graft and progress in understanding humoral memory led...

The human leukocyte antigen (HLA) genes on chromosome 6 are instrumental in many innate and adaptive immune responses. The HLA genes/haplotypes can also be involved in immune dysfunction and autoimmune diseases. It is now becoming apparent that many of the non-antigen-presenting HLA genes make significant contributions to autoimmune diseases. Interestingly, it has been reported that autism subj...

Abstract Immunotherapeutic approaches in cancer aim to booster T cell mediated immune responses. Tumor-specific cells recognize target via human leukocyte antigen (HLA) molecules before specific lysis is initiated. Malignant gliomas are known for their immunoevasive and immunosuppressive properties which impede effective tumor-specific responses, including clinical responses checkpoint inhibiti...

Human leukocyte antigen (HLA) class I molecules are critical components of the cell-mediated immune system that bind and present intracellular antigenic peptides to CD8(+) T cell receptors. To understand the interaction mechanism underlying human leukocyte antigen (HLA) class I specificity in detail, we studied the structural interaction characteristics of 16,393 nonameric peptides binding to 5...

systemic lupus erythematosus (sle) is an autoimmune disease in which polymorphisms within the human leukocyte antigen (hla) region have been associated to its etiology. we conducted this study to compare the hla-dqb1 allelic sequence variation among sle patients and controls in the northeast of iran. genomic dna of 40 sle patients and 83 healthy controls were amplified by polymerase chain react...