The three-dimensional (3D) structures of human leukocyte antigen (HLA) molecules are indispensable for the studies on the functions at molecular level. We have developed a homology modeling system named HLA-modeler specialized in the HLA molecules. Segment matching algorithm is employed for modeling and the optimization of the model is carried out by use of the PFROSST force field considering t...

Objectives: Despite the improvements in early-term outcomes of kidney transplantation, late-term graft failure still remained as a critical problem. De novo donor specific antibodies (DSA) developing against direct human leukocyte antigens (HLA) are significant risk factors for shortened survival previously non-sensitized cases. The purpose this study is to evaluate clinical de DSA development ...

The human leukocyte antigen (HLA) complex is a series of genes located on chromosome 6 that are important in normal immune function. Susceptibility to chronic beryllium disease, a granulomatous lung disease that appears in workers exposed to beryllium, is modified by genetic variants of the HLA-DP subregion. Evaluation of HLA-DPB1 sequence motifs in current and former beryllium workers implicat...

Human leukocyte antigens (HLA) in patients with Graves' disease were investigated according to the ophthalmic classification system of the American Thyroid Association. All prior HLA studies of Graves' disease have disregarded the patients' specific ophthalmic manifestations. Examination of 18 A and 34 B loci antigens disclosed an increased frequency (corrected P = 0.002, relative risk = 13.1) ...

selective iga deficiency (igad) (serum iga concentration of pcr was used to type hla b, dr, and dq alleles in 29 iranian individuals with igad and 299 swedish individuals with igad. the results indicate a strong association with the hla b14, dr1 alleles in iranian subjects and hla b8, b12, b13, b14, b40, dr1, dr3, dr7, dq2 and dq5 alleles in swedish subjects. differences in hla association of i...

HLA (Human Leukocyte-A) antigens of 20 patients with toxoplasmic retinochoroiditis were determined by the standard microlymphocyte cytotoxicity test to see if these patients have different immunogenetic backgrounds from the normal controls. The results showed that there were no significant differences between the patients and the normal controls.

Submit Manuscript | http://medcraveonline.com Abbreviations: CDC: Complement Dependent Cytotoxicity; FCXM: Flow-Cytometry Crossmatch; SAB: Single Antigen Bead; ESRD: End Stage Renal Disease; AMR: Antibody Mediated Rejection; DSA: Donor Specific Antibodies; MFI: Mean Fluorescence Intensity; DSA: Donor Specific Antibodies; HLA: Human Leukocyte Antigens; PRA: Panel Reactive Antibody; MCS: Median C...

The goal of tumor immunotherapy is to elicit immune responses against autologous tumors. It would be highly desirable that such responses include multiple T cell clones against multiple tumor antigens. This could be obtained using the antigen presenting capacity of dendritic cells (DCs) and cross-priming. That is, one could load the DC with tumor lines of any human histocompatibility leukocyte ...

Sixty individuals were typed for D-related human leukocyte antigens (HLA-DR) using two methods: the standard eosin exclusion method and a recently described one-color ethidium bromide technique. As a result, 88 of the 90 DR antigens detected by the standard technique were also detected by one-color fluorescence (sensitivity = 97.8 percent). However, of the 99 DR antigens identified by ethidium ...

Human Leukocyte Antigens (HLA) of fetus are responsible for induction of HLA antibodies in mother. Exposure to the mismatched paternal HLA antigens in the fetus gives rise to a polyclonal antibody response against paternal HLA antigens. HLA antibodies are present in the maternal circulation of the placenta and are absorbed onto the placenta [1]. The major source of HLA antisera is from sera of ...