Corticotropin-releasing hormone (CRH), a hypothalamic neuropeptide involved in the regulation of ACTH secretion, has been detected by RIA in extracts of human placenta. We wished to determine whether this immunoreactive substance is a product of CRH gene expression in the placenta. We have found authentic human CRH (hCRH) mRNA in human placental tissue that is similar in size to hypothalamic CR...

Placenta is the most important and vital organ of intrauterine life. It is fountainhead of human existence. The placenta is formed from elements of membrane which surround the developing fetus and the uterine endometrium and provide the means for physiological exchange between the fetal and maternal circulation and it shows various histological and histochemical changes in case of diabetic moth...

A mucin-type glycoprotein has been described in murine, rat and canine tissues as a differentiation antigen and influenza-virus receptor. We have cloned a cDNA from human placenta RNA encoding the corresponding human protein, a type-I integral membrane protein of 162 amino acids. Madin-Darby canine kidney cells transfected with the cDNA clone directed the cell-surface expression of a 36-kDa O-g...

BACKGROUND As there is no optimal treatment of non small cell lung cancer due to its resistance to common chemotherapeutics, we investigated the effect of human placenta-conditioned medium on tumor tissue. The human placenta constitutes a mixture of maternal and fetal origin and displays a variety of immunomodulatory aspects. METHODS Freshly resected non small cell lung cancer tissues were in...

The human newborn is a reflection of the entirety of nutrients transferred from the maternal to the fetal circulation across the placenta during gestation. By extension, birth weight and newborn health depend on placental function. In this article, we quantify efficiency of the transport system in the human placenta and study its role played in the birth weight as well as the gestational age of...