OBJECTIVE To investigate the clinicopathological correlation of parapapillary atrophy. MATERIALS AND METHODS The study included 16 eyes of rhesus monkeys (Macaca mulatta) - 4 eyes with experimental glaucoma, 11 eyes after experimental temporary occlusion of the central retinal artery, and 1 normal eye. On histological sections, we measured zones with different histological characteristics.On ...

Repare In order to purify and characterize retinal pigment epithelial proteins exhibiting uveitogenic characteristics upon immunization of Lewis rats, a broad panel of monoclonal antibodies directed against retinal pigment epithelial (RPE) protein antigens, was isolated. Merh&s Bovine RPE detergent extracts were used to isolate monoclonal antibodies against RIPE antigens. Species and tissue spe...

Repare In order to purify and characterize retinal pigment epithelial proteins exhibiting uveitogenic characteristics upon immunization of Lewis rats, a broad panel of monoclonal antibodies directed against retinal pigment epithelial (RPE) protein antigens, was isolated. Merh&s Bovine RPE detergent extracts were used to isolate monoclonal antibodies against RIPE antigens. Species and tissue spe...

OBJECTIVE To determine the effects of Smad7 gene transfer in the prevention of fibrogenic responses by the retinal pigment epithelium, a major cause of proliferative vitreoretinopathy after retinal detachment, in mice. METHODS Retinal detachment-induced proliferative vitreoretinopathy in a mouse model. Forty-eight eyes received either an adenoviral gene transfer of Smad7 or Cre recombinase ge...

Ocular albinism type 1 (OA1) is an inherited disorder characterized by severe reduction of visual acuity, photophobia, and retinal hypopigmentation. Ultrastructural examination of skin melanocytes and of the retinal pigment epithelium reveals the presence of macromelanosomes, suggesting a defect in melanosome biogenesis. The gene responsible for OA1 is exclusively expressed in pigment cells and...

Repare In order to purify and characterize retinal pigment epithelial proteins exhibiting uveitogenic characteristics upon immunization of Lewis rats, a broad panel of monoclonal antibodies directed against retinal pigment epithelial (RPE) protein antigens, was isolated. Merh&s Bovine RPE detergent extracts were used to isolate monoclonal antibodies against RIPE antigens. Species and tissue spe...