Transplanting bioengineered human lung organoids into mice could lead to a humanized model for pre-clinical studies of lung disease.

Spin-wave devices (SWD), which use collective excitations of electronic spins as a carrier of information, are rapidly emerging as potential candidates for post-semiconductor non-charge-based technology. Isotropic in-plane propagating coherent spin waves (magnons), which require magnetization to be out of plane, is desirable in an SWD. However, because of lack of availability of low-damping per...

Epstein–Barr virus (EBV) is the prototypic human tumor whose continuous lifelong immune control required to prevent lymphomagenesis in more than 90% of adult population that are healthy carriers virus. Here, we review recent evidence this has not only target latent oncogenes, but also lytic replication EBV. Furthermore, genetic variations identify molecular machinery cytotoxic lymphocytes as es...

We generated a new humanized mouse model to study HLA-restricted immune responses. For this purpose, we created unique murine hosts by enforcing the expression of human SIRPα by murine phagocytes in murine MHC-deficient HLA-transgenic alymphoid hosts, an approach that allowed the immune reconstitution of nonpermissive mice following injection of human hematopoietic stem cells. We showed that th...

Intraperitoneal administration of ICSM18 and 35, monoclonal antibodies against prion protein (PrP), has been shown to significantly delay the onset of prion disease in mice, and humanized versions are candidate therapeutics for prion and Alzheimer's diseases. However, a previous report of severe and widespread apoptosis after intracerebral injection of anti-PrP monoclonal antibodies raised conc...

Citation: Waltari E, Jia M, Jiang CS, Lu H, Huang J, Fernandez C, Finzi A, Kaufmann DE, Markowitz M, Tsuji M and Wu X (2018) 5′ Rapid Amplification of cDNA Ends and Illumina MiSeq Reveals B Cell Receptor Features in Healthy Adults, Adults With Chronic HIV-1 Infection, Cord Blood, and Humanized Mice. Front. Immunol. 9:628. doi: 10.3389/fimmu.2018.00628 5′ rapid amplification of cDna ends and ill...

Background: The preclinical evaluation of novel immune therapies demands humanized mouse models with functional human cells. In previous studies we have established a system T- B- and NK cells, as well monocytes in immunodeficient mice by transfer hematopoietic stem cells (HSCs) or peripheral blood mononuclear (PBMC). By transplantation cell-line-derived (CDX) patient-derived (PDX) tumor xenogr...

Regulatory T cells (Treg) control immune cell function as well as non-immunological processes. Their far-reaching regulatory activities suggest their functional manipulation as a means to sustainably and causally intervene with the course of diseases. Preclinical tools and strategies are however needed to further test and develop interventional strategies outside the human body. "Humanized" mou...

Two studies tested the conditions under which an environment (e.g., library, restaurant) raises the relevance of environment-specific social norms (e.g., being quiet, using table manners). As hypothesized, the relevance of such norms is raised when environments are goal relevant ("I am going there later") and when they are humanized with people or the remnants of their presence (e.g., a glass o...

Two novel approaches of recombinant PCR technology were employed to graft the complementarity determining regions from a murine monoclonal antibody (mAb) onto human antibody frameworks. One approach relied on the availability of cloned human variable region templates, whereas the other strategy was dependent only on human variable region protein sequence data. The transient expression of recomb...