BACKGROUND Low- and high-frequency stimulation (LFS and HFS, respectively) have been, reported to modify seizure characteristics in rats. We here report effects of hippocampal LFS and HFS, applied at two or four sites in fully kindled rats. METHODS Rats were kindled through a hippocampal tetrode until the fully kindled state. Animals with, stable afterdischarge (AD) threshold were randomly as...

Human fecal pollution of recreational waters remains a public health concern worldwide. As a result, there is a growing interest in the application of human-associated fecal source identification quantitative real-time PCR (qPCR) technologies for water quality research and management. However, there are currently no standardized approaches for field implementation and interpretation of qPCR dat...

Patients with splenomegaly may come to medical attention for a variety of reasons. However, patients with no obvious explanation for an enlarged spleen present a difficult diagnostic problem. A detailed history taking, appropriate clinical examination and relevant investigations is tool for a diagnosis of splenomegaly. Appropriate investigations in most patients with undiagnosed splenomegaly wi...

In less than a decade, the resources available to treat light chain (AL) amyloidosis have increased impressively. Physicians involved in the care of patients with this disease, which not so long ago was considered untreatable, now need to learn how best to use the many different available treatment approaches. Fortunately, in these same years our ability to identify patients at risk and to asse...

We report here a case of a 35-year-old male who presented with multi-system disease, which on evaluation was found to be due to primary systemic amyloidosis. We present the myriad manifestations of this uncommon disease entity.

Information regarding the association between prehypertension BP level and renal arteriosclerosis is limited. In 652 consecutive population-based autopsy samples without hypertension treatment before death, the relationship between the severity of renal arteriosclerosis and BP levels classified according to the criteria of the Seventh Report of the Joint National Committee on Prevention, Detect...

A universal description of the hyperfine splittings (HFS) in bottomonium and the Bq (q 1⁄4 n, s, c) mesons is obtained with a universal strong coupling constant sð Þ 1⁄4 0:310 in a spin-spin potential. Other characteristics are calculated within the field correlator method, taking the freezing value of the strong coupling independent of nf. The HFS MðB Þ MðBÞ 1⁄4 45:5ð1Þ MeV, MðB sÞ MðBsÞ 1⁄4 4...

High-frequency return, trading volume and transaction number are digitally coded via a nonparametric computing algorithm, called hierarchical factor segmentation (HFS), and then are coupled together to reveal a single stock dynamics without global state-space structural assumptions. The base-8 digital coding sequence, which is capable of revealing contrasting aggregation against sparsity of ext...

Today´s connected world allows people to gather information in shorter intervals than ever before, widely monitored by massive online data sources. As a dramatic economic event, recent financial crisis increased public interest for large companies considerably. In this paper, we exploit this change in information gathering behavior by utilizing Google query volumes as a "bad news" indicator for...