Small molecules that increase the oxygen affinity of human hemoglobin may reduce sickling of red blood cells in patients with sickle cell disease. We screened 38,700 compounds using small molecule microarrays and identified 427 molecules that bind to hemoglobin. We developed a high-throughput assay for evaluating the ability of the 427 small molecules to modulate the oxygen affinity of hemoglob...

Carbohydrates that migrate to wood surfaces in sapwood during drying might influence properties such as mould susceptibility and colour. Sugars on the surface of Norway spruce boards during various heat treatments were studied. Samples (350mmx125mmx25mm) were double-stacked, facing sapwood-side outwards, and dried at 110C to a target moisture content (MC) of 40%. Dried sub-samples (80 mm x 125 ...

Introduction 5-Hydroxymethyl-2-furaldehyde (HMF), as diformylfurane precursor (DFF), is obtained from fructose or glucose dehydration. DFF is a versatile chemical, and there are numerous reports describing various applications as a monomer, as starting materials for the synthesis of pharmaceuticals and antifungal agents [1]. To date, few reports describe the use of air to oxidize (HMF) with het...

In this study, a microwave-assisted process was developed for the production of 5-hydroxymethylfurfural (HMF), furfural, and hydrochar from bamboo (Phyllostachys nigra “Boryana”) in biphasic reaction system. The system consisted an acidified aqueous phase methyl isobutyl ketone (MIBK) as organic enabled instantaneous extraction HMF furfural phase. way, unwanted side rehydration reactions are av...

Zygomycetes fungi are able to produce ethanol, and their biomass may hold a high market value, making them interesting microorganisms from a biorefinery perspective. In the present study, the inhibitor tolerance of the Zygomycetes fungus Rhizopus sp. was evaluated and compared with a flocculating strain of Saccharomyces cerevisiae. The inhibitors furfural, 5hydroxymethylfurfural [HMF], acetic a...

With an increasing demand for safe and natural products from both industries consumers, paired with the recent ban of decried molecules (i.e. octinoxate, avobenzone or octocrylene) due to their high negative impact on humans environment endocrine disruption, coral bleaching), bio-based alternatives are a necessary promising surrogate substitute current commercialized petroleum-based UV filters....

Lignocellulosic biomass has been recognized as a promising feedstock for the fermentative production of biofuel. However, the pretreatment of lignocellulose generates a number of by-products, such as furfural, 5-hydroxylmethyl furfural (5-HMF), vanillin, vanillic acids and trans-p-coumaric acid (TPCA), which are known to inhibit microbial growth. This research explores the ability of Rhodococcu...

some physicochemical parameters of honey have been introduced by the international honey commission to evaluate its quality and origin but processes such as heating and filtering can affect these parameters. in traditional iranian medicine, deslagging process involves boiling honey in an equal volume of water and removing the slag formed during process. the aim of this study was to determine th...

Lignocellulose-derived inhibitors have negative effects on the ethanol fermentation capacity of Saccharomyces cerevisiae. In this study, the effects of eight typical inhibitors, including weak acids, furans, and phenols, on glucose and xylose co-fermentation of the recombinant xylose-fermenting flocculating industrial S. cerevisiae strain NAPX37 were evaluated by batch fermentation. Inhibition ...