The aim of the present study was to prepare and evaluate an osmotically controlled mucoadhesive cup-core (OCMC) containing aceclofenac. A special technique was used while preparing an OCMC. Stability of OCMC was determined in natural human saliva, and it was found that both pH and device are stable in human saliva. OCMC was evaluated by weight uniformity, thickness, hardness, friability, swelli...

OBJECTIVES/HYPOTHESIS The purpose of this study was to determine the usefulness of edible taste strips for measuring human gustatory function. STUDY DESIGN The physical properties of edible taste strips were examined to determine their potential for delivering threshold and suprathreshold amounts of taste stimuli to the oral cavity. Taste strips were then assayed by fluorescence to analyze th...

The pervasiveness of tribo-electric charge during pharmaceutical processing can lead to the exacerbation of a range of problems including segregation, content heterogeneity and particle surface adhesion. The excipients, hydroxypropyl methylcellulose (HPMC) and methylcellulose (MC), are often used in drug delivery systems and so it is important to understand the impact of associated factors on t...

The effect of dietary feeding of hydroxyethyl methylcellulose (HEMC) and hydroxypropyl methylcellulose (HPMC) on the glucose metabolism and antioxidative status in mice under high fat diet conditions was investigated. The mice were randomly divided and given experimental diets for six weeks: normal control (NC group), high fat (HF group), and high fat supplemented with either HEMC (HF+HEMC grou...

Depression is a mental illness causing continuous negative feeling and loss of interest affects physical health. Mirtazapine (MTZ) an effective medicine for treating depression, but patients lack compliance. However, transforming pharmaceutical dosage form to orodispersible film (ODF) could resolve this issue. This study aims fabricate ODF-loading mirtazapine, using syringe extrusion 3D printer...

This study used oleogels to resolve unsolidified white chocolate in 3D printing. Because cannot be shaped during printing, the oleogel system is solve this problem. The printing parameters and accuracy a were investigated by using different added as material enhance extrusion solidification, monoglycerides (MAG), sucrose fatty acid ester (SE) hydroxypropyl methylcellulose (HPMC), their effects ...

      Extended release formulation of alfuzosin, an a-antagonist used for prostatic hypertrophy, is available in market. It is convenient for older patients to take only one tablet a day. Marketed alfuzosin formulation is three layered geomatrix tablet that requires special facilities, high cost, more time and complex operation than normal direct compression formulation. Therefore, a less compl...