نتایج جستجو برای: hyper ige syndrome
تعداد نتایج: 654501 فیلتر نتایج به سال:
BACKGROUND Hyper IgE syndrome (HIES) is a rare primary immunodeficiency disorder characterized by the triad of elevated IgE and eosinophilia, eczema and recurrent skin and pulmonary infections. Mutation in the STAT3 gene accounts for majority of the autosomal dominant and sporadic forms of HIES. OBJECTIVE To report clinical and molecular analyses of patients with Hyper IgE syndrome from a sin...
Introduction: Juvenile idiopathic arthritis (JIA) represents a heterogeneous group of childhood chronic arthritic conditions. The pathogenesis of JIA remains incompletely understood. This disease can lead to a significant morbidity including joint deformity, growth impairment and a persistence of active arthritis into adulthood. The past two decades have witnessed significant advances in treatm...
The novel cytokine IL-31 and its receptor have been shown to play a central role in bridging the immune system with neurons, epithelial surfaces connective tissues. Although increasing evidence has demonstrated their inflammation, involvement expansion of distinct leukocyte subsets is not fully understood. Detailed analyses Il31-transgenic (Eμ-Lck) mice indicated that next induction pruritus sk...
The novel cytokine IL-31 and its receptor have been shown to play a central role in bridging the immune system with neurons, epithelial surfaces connective tissues. Although increasing evidence has demonstrated their inflammation, involvement expansion of distinct leukocyte subsets is not fully understood. Detailed analyses Il31-transgenic (Eμ-Lck) mice indicated that next induction pruritus sk...
Hyper-IgE syndrome (HIES), also called Job’s syndrome, [Online Mendelian Inheritance in Man (OMIM) #147060 and #243700] is a rare primary immunodeficiency disease, with an incidence lower than 1/10, not gender related, transmitted as an autosomal dominant or recessive trait with variable expressivity and of unknown etiology. HIES has been defined as a multisystem disease characterised by: 1) ex...
Elevated IgE levels can be associated with a variety of causes. The diagnosis is most often made on a clinical basis taking into consideration a complete history and physical. In this case report we describe a patient with elevated IgE levels and our discovery upon further investigation after noticing some unique findings on his physical examination. The differential diagnosis of extremely elev...
BACKGROUND The hyper-IgE syndrome (HIES) is a primary immunodeficiency characterized by infections of the lung and skin, elevated serum IgE, and involvement of the soft and bony tissues. Recently, HIES has been associated with heterozygous dominant-negative mutations in the signal transducer and activator of transcription 3 (STAT3) and severe reductions of T(H)17 cells. OBJECTIVE To determine...
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