hyper ige syndrome (hies) is a rare primary immunodeficiency disease. most of hies cases are sporadic. hies type ad is caused by mutation in signal transducer and activator of transcription-3 (stat-3). a number of mosaicism hies has been reported that is associated with intermediate phenotype. autosomal recessive hies (ar-hies) is due to mutation in dock-8 or cytokine sis 8 and tyk2 or tyrosine...

background: asthma is a multifactorial disease and its severity varies with the inflammatory grade. there are conflicting reports about the roles of trace elements in asthma. this study examined the effects of zinc (zn), copper (cu), and selenium (se) concentrations in sera of patients with allergic asthma attending ghaem hospital, mashhad, iran. methods: forty-nine patients, aged 10 to 50 year...

hyper-igm syndromes are characterized by profound reduction of serum igg, iga, and ige levels with normal or increased concentrations of serum igm. cd40 ligand deficiency is x-linked form of the disease, which results in a lack of immunoglobulin class switching from igm to igg in b cells. in addition to the recurrent infections, a number of patients suffer from neutropenia. there are some evide...

presence of distributed generation (dg) in electric distribution systems provides an attractive new alternative in capacity expansion planning of these systems. in this paper a new model is developed for solving simultaneous placement of hv/mv substations and dg units as a static planning tool. this model aims to minimize fixed and variable costs of planning. constraints related to dgs, substat...