Determining the unknown material parameters of intact ventricular myocardium can be challenging due to highly nonlinear material behavior. Previous studies combining a gradient-search optimization procedure with finite element analysis (FEA) were limited to two-dimensional (2D) models or simplified three-dimensional (3D) geometries. Here we present a novel scheme to estimate unknown material pa...

Inconclusive findings regarding the collagen fiber architecture and the material properties of the glenohumeral capsule make it unclear whether the material symmetry of the glenohumeral capsule is isotropic or anisotropic. The overall objective of this work was to use a combined experimental and computational protocol to characterize the mechanical properties of the axillary pouch of the glenoh...

In breast elastography, breast tissues usually undergo large compressions resulting in significant geometric and structural changes, and consequently nonlinear mechanical behavior. In this study, an elastography technique is presented where parameters characterizing tissue nonlinear behavior is reconstructed. Such parameters can be used for tumor tissue classification. To model the nonlinear be...

Mathematically describing the mechanical behavior of soft tissues under large deformations is of paramount interest to the medical simulation community. Most of the data available in the literature apply small strains (<10%) to the tissue of interest to assume a linearly elastic behavior. This paper applies a nonlinear hyperelastic 8-chain network constitutive law to model soft tissues undergoi...

The coupling of new medical imaging data, fractional anisotropy and axonal fiber orientation from Diffusion Tensor Imaging (DTI) of 12 healthy patients called the DTI atlas with the Strasbourg University Finite Element Head Model has been done to improve the brain constitutive material law with more efficient improved heterogeneous anisotropic visco‐hyperelastic material la...

An extension of the generalized finite element method to the class of mixed finite element methods is presented to tackle heterogeneous systems with nearly incompressible non-linear hyperelastic material behavior. In particular, heterogeneous systems with large modulus mismatch across the material interface undergoing large strains are investigated using two formulations, one based on a continu...