Hypereosinophilic syndrome (HES) is classically defined as prolonged, unexplained peripheral eosinophilia in a patient presenting with evidence of end-organ damage. The heart is involved in two forms; endomyocardial fibrosis (Davies disease) and eosinophilic endocarditis (Loffler's endocarditis). It was first reported in 1968 by Hard and Anderson. Chusid and co-workers formulated a definition w...

Idiopathic hypereosinophilic syndrome (HES) comprises a heterogeneous group of disorders characterised by prolonged eosinophilia with no obvious cause. A patient with longstanding HES is reported in whom unusual non-neoplastic peritrabecular lymphoid aggregates were present in the bone marrow, a hitherto undescribed association, as far as is known. An eosinophil colony stimulating activity was ...

Hypereosinophilic syndrome (HES) is a heterogeneous group of hematological disorders characterized by a chronic, unexplained hypereosinophilia with tissue damage. Cardiac involvement occurs in ∼20% of patients with HES and represents a major turning point. Cardiac injuries related to eosinophilia are divided into three chronological phases: eosinophilic infiltration, thrombosis, and fibrosis. W...

The hypereosinophilic syndrome is a group of diseases characterised by persistent blood eosinophilia, defined as more than 1500 cells per micro liter [1], with end-organ involvement and no recognised secondary causes such as skin diseases, parasitic infection or allergy (Table). The sustained overproduction of eosinophils causes eosinophilic infiltration and release of mediators causing damage ...

Any chronic hypereosinophilic state, including eosinophilic leukemia, reactive eosinophilia and idiopathic hypereosinophilic syndrome may be complicated by the end-organ damaging effects of eosinophilic degranulation, especially cardiac involvement. Several cytogenetic abnormalities that have prognostic and even therapeutic implications, have been described in patients with different variants o...

The hypereosinophilic syndrome is a rare disease characterized by the association between high absolute eosinophil count and eosinophil-mediated organ damage. We describe a case of a 70-year-old male with an absolute eosinophil count of 2130 cells/µL. Clinical symptoms and signs included the following: severe asthenia, axonal sensitive motor neuropathy, basal pleural effusion with signs of hypo...

OBJECTIVE To describe 3 cases of stroke associated with hypereosinophilic syndrome and discuss the pathogenesis of such strokes. DESIGN Retrospective medical record review. SETTING University hospital. PARTICIPANTS Three patients who had strokes temporally correlating with eosinophilia with no other obvious causes of stroke. INTERVENTION Retrospective review of the hospital course, labo...

253 Correspondence to: Tomasz Miszalski‐Jamka, MD, PhD, Zakład Radiologii Lekarskiej i Diagnostyki Obrazowej, 4. Wojskowy Szpital Kliniczny z Polikliniką, ul. Weigla 5, 50-981 Wrocław, Poland, phone/fax: +48-71-766-04-80, e-mail: [email protected] Received: March 24, 2013. Revision accepted: March 27, 2013. Conflict of interest: none declared. Pol Arch Med Wewn. 2013; 123 (5): 253-254 Copyright by ...