Hypericum species, growing wild in Anatolia, widely used in traditional medicine in Turkey. In order to determine the genotoxic effect of Hypericum heterophyllum, human lymphocytes were incubated with the aqueous extracts. The increasing extract concentrations of Hypericum heterophyllum induced micronucleus. The rise of micronucleus shows that Hypericum heterophyllum at high concentrations may ...

essential oils from aerial parts of mentha spicata, was obtained by steam destillation using a clevenger-type system. these oils were screened for antibacterial and anti-candida albicans activity using bioautographic method. a fiel experiments was laid out in agricultural research farm, city namin, ardabil province, iran in 2013. experiment was conducted in a randomized complete block with seve...

background & aim: the world production and consumption of essential oils and perfumes are increasing very fast. lippia citriodora h.b.k. is an herbal species mainly used as a spice and medicinal plant. endogenous levels as well exogenous application of plant growth regulators (pgr) could affect essential oil production and chemical compositions. experimental: to study the effect of exogenou...

Background & Aim: Vast variety of plants in various regions of the country and lack of enough information on their chemical combinations, sometimes lead to triggering poisoning and unsatisfied complications. Regarding to fabulous herbal characteristics of Hypricum, many research about poisoning and side effects of high concentrations of H. scabrum have not taken place...

Herb-drug interactions are an important safety concern and this study was conducted regarding the interaction between the natural top-selling antidepressant remedy Hypericum perforatum (Hypericaceae) and conventional drugs. This study examined the influence of acute pretreatment with different extracts of Hypericum perforatum from Serbia on pentobarbital-induced sleeping time, impairment of mot...

UNLABELLED PHARMACOLOGICAL RELEVANCE: Presentation of the scratch assay as a convenient and inexpensive in vitro tool to gain first insights in the wound healing potential of plant extracts and natural compounds. AIM OF THE STUDY The present study deals with the optimization of the scratch assay which can be used as an in vitro model for quantification of fibroblast migration to and prolifera...

OBJECTIVE To investigate the efficacy of hypericum extract WS 5570 (St John's wort) compared with paroxetine in patients with moderate to severe major depression. DESIGN Randomised double blind, double dummy, reference controlled, multicentre non-inferiority trial. SETTING 21 psychiatric primary care practices in Germany. PARTICIPANTS 251 adult outpatients with acute major depression with...

St John's wort (Hypericum perforatum) is a traditional herbal medicine that is used for the topical treatment of superficial wounds, burns and dermatitis. The characteristic metabolites of St John's wort are the photodynamic active plant pigment hypericin and the phloroglucin-derivative hyperforin. To date, no studies on immunomodulatory properties of topical preparations of St John's wort have...

OBJECTIVES To assess the efficacy and safety of hypericum extract (STEI 300, Steiner Arzneimittel, Berlin) compared with imipramine and placebo in patients in primary care with a current episode of moderate depression. DESIGN Randomised, double blind, multicentre, parallel group trial for 8 weeks. SETTING Trained panel of 18 general practitioners from four German states: Bavaria, Berlin, Rh...

background & aim: ziziphora l. genus belongs to the lamiaceae family, which has important medicinal and aromatic plant species. in current study, essential oil chemical compositions of two ziziphora l. species (z. tenuior l. and z. clinopodioides lam.) were investigated. experimental: the flowering branches of z. tenuior and z. clinopodioides were collected in spring and summer 2011. the ae...